ID A0A267G889_9PLAT Unreviewed; 655 AA.
AC A0A267G889;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig020191g1 {ECO:0000313|EMBL:PAA82253.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA82253.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA82253.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA82253.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA82253.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA82253.1}.
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DR EMBL; NIVC01000483; PAA82253.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267G889; -.
DR STRING; 282301.A0A267G889; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF32; FI22325P1; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..217
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 267..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA82253.1"
SQ SEQUENCE 655 AA; 70466 MW; 5DB9976F24AC7968 CRC64;
TTFATLYFRV KHYPPYPTDN LKQSLSKYLL YCQLKLDLLE GRLYSSNSRD IVHLAACIVQ
AEFGDFDSIA GFEHRDYLGG VVLSHNQTPK LESLIYEEHA TLKGKSTQEA EAMFLEKAFA
LDTYGIEPKP VRDRNGNSLF LGLSHRAVVT FHGSKLTHSF AWESINHIRV QDKMLLLEIN
LSSTKRHLLG FKCESKAAAS ALWASSLEQQ LFFTLNKGSE ARVVKSNDGF LRRRRNSFRF
SGRSQKELLS SSNYFLNVEQ TAPPVVRVKR SSSMSSCPTV RRLPSVRKRL RYSSSDSSDG
SDISSVSQSR RAQANQAEAA KRDTASSTRF ATYPGRKRPE VEEAMEAHDQ ASSGVAPESD
RRTDSKADSK ADSKADSKAD SKADSKADSV FEDRQGLAAS SAAASSHAAT GESEASAKAA
SSASSAASGA KEAGEQSAGV EVAQSSDLGL GDGAPASEGD AEVKDVQQDQ YAEEVTDEAV
VAAVSSATVE SASPIEGSLT AANGNINPTE VDEVHPVEPE ETPTTVAVAS AESFDDNAAV
AELDQVLEHH EVVKEEAGIA AAVVAASAAA SNGNSSVSTN QHRDTAATAS DLIRPVSRTQ
AALVLTAAFS LLTLVGLVLF YEANLTSPTM RSLREHPLVH EFYDRVYAPI RGRLV
//
