ID A0A267GEC3_9PLAT Unreviewed; 1842 AA.
AC A0A267GEC3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=TRPM SLOG domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig021629g1 {ECO:0000313|EMBL:PAA84380.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA84380.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA84380.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA84380.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA84380.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA84380.1}.
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DR EMBL; NIVC01000376; PAA84380.1; -; Genomic_DNA.
DR STRING; 282301.A0A267GEC3; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF12; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 851..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1038..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1120..1142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1265..1284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..327
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 980..1241
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1497..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 877..914
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1522
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1842 AA; 207920 MW; EBC657F5AB778245 CRC64;
MDFPHPGVSS TTGWGPASSA GAASIASVSA TAAASVGAGG GGSFRRQSLK QQQQQQNEEA
SKTFGEIEFS GLKQLAKFVR LDSNTPDSAL QQILGKKWDL TRPTLVINIF GGDFEKKRQL
KMIFKKGLWK AAESAGCWIV TSGFHLGIMK LTGEAVRDYT DAYGSNYMIA IGVASWNCIA
RREALEDPNI SEGSVPATYQ SEESDSSKPK ELRASDEDES PLDPNHTHYF LVDTGATDQK
KGYDCPFRTR FSHVISSWTD EENKQLKVPM CGLLIGGDRF ALEQVFYALT ETKCPIVAVK
GTAGAADVLS SAFDYLFEEE NQVDKKEEDE ETQEANFNSK MSNICQEFFN CNDYFDYTKE
IDMLRVMLKE GASLIEIFDM EEDFDLDGKM ISSLLSSAGS EGGEDQLNLK QLKICLTLNR
ADIARDKIFL ENKKWKKGDL NEYMYQALME DRHDFVKLFL EQGFSLEDFL SIYILEKLYT
DQLKRLSSKV AIFHQLWEYH RSHRNSKKVK LREVGKVIKV LVGDFYQPLY AKKDFEKNYT
KSVVTAQSPV DQSTTKALVQ TAQTGYLPAY FFTKSGPGQN SGSDAAGVGG DNMPQAVPKR
RRLQAGDGSQ ETQLEICEYE RSPINFSGRD DDTSDSNARG YENPIMESSS DSQANASGSR
ATQRAGHRWR GAAKRQGGKT KPRFAELTSM LSEARPLIGI GPSPAQAEET RAKSLTLERP
ARELLIWSLL VGKLQMAELF WTMEKEPIAA ALLSSMILKA MGGRTDDFTD KEDFQRGASQ
FEDYALGVLD QCYREDERRA QFLINRELAF YGDSSCIYLA AEGESIKFMA HPCCQDFLTS
TWMGRLSPKN AMARFSFGIL CGMCCPLLIP KVMLFKLTEE EAQKQQAITQ QQQQQEEQQQ
QQQQQLQLQQ QQRQQQLVKT PSPEGVVVDM NEDGEEAQYY PGQENVQSSE SLNCRQVIAR
IRDFYMAPVI RFVYNTISYV AFLVIFSYML LYELTHAIKP LEYVVIGWMV TLLLEEIKQA
TMSGISFSTY ISDSWNKLDC IAVGLFTLGF ILRMISLISD VQSDEPGYDV ILTSEFFIIA
RICYAFSLFA YYIRLMYIFS FHIALGPKLI MIGKMVINDL VPFMVILLVF VLGYGVAAQS
IAYPTGLYTP EIDYNKTFPP RMSQMEVLVN FLTKSYFQMF GEFSLETVQA RDDGCKNDGQ
CPHWTATWLV PVMLGVYVLL TNILMFNLLI AMFSSTYELI NQFSALHWNY QRYSMIKEYI
ERSPLAPPLI FIWHAYQLGF YIQLRYNGLR RSDLYDPLKI KYIDNVKKER ELIKWEHMKA
MDYLRNGQEA QQKSRGGRGD SKSIIVRTSG PQPAAGGGQS MFPSAAMDMA KQMTDATSGI
GMELEKKFKG VDTQLNKLGA DLDGRVGELS TAVQGVSQLL ASVQETQRQI LEKLGERPTE
PIPAVDPQLE SRVRSVVLEM YQAPPAWFEE AARQAASAAL QTTPVSVREL GSPVLERLRP
VQAPPPKPPT PPPPPPEEPP SPEEESSSSE SDDDDRTTVR PQVDDPTTGR IIQYLTSDHR
LWRYAPFNFE QYPGMRMNVP PDRIPWEIEY REYFAFDASD EVLVYPGPDA HDNPSVSVHS
LPFNQYDSAH KLRRQSMMGR YRLDSNSGAP LNPMGRTGLK GKGLLPRWGP NNAAVVVMTR
WNRAPSGAVI HRLGKPILQV VSLFRHKQFC LPWYLTDHQS HCDYDQCVAQ FLKVFVSRRL
KQLMQHRGAR QEITAVQKGR AEQIFKGYLD DHLNSDNAWI EAVVINIHES EGWKFSDAML
KVFAEADCDE QVKWMEVAYS TALRSSHCEL LKTVAGNHNA YF
//
