ID A0A267GFJ5_9PLAT Unreviewed; 480 AA.
AC A0A267GFJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|PROSITE:PS50255};
GN ORFNames=BOX15_Mlig019763g2 {ECO:0000313|EMBL:PAA84207.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA84207.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA84207.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA84207.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA84207.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA84207.1}.
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DR EMBL; NIVC01000385; PAA84207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GFJ5; -.
DR STRING; 282301.A0A267GFJ5; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR018506; Cyt_B5_heme-BS.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF82; CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..144
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
SQ SEQUENCE 480 AA; 55183 MW; 8112F105B04D7D0B CRC64;
MVSHRLGKHQ SECNASISAK AATFKIRETN KHELAAQDSE TEEDSSRNGF SCIRRSNCAL
KIPADAPTRT EAYKAYMSSH PTAKLIGING GWYDISKFIP HHPGGSVIAQ FVGKDATPVF
KGLHTKDVLK NMRPVATYRL SEADPAAEAF AELHQFFIKQ GFFQTSAVWY AGKMAFAASL
LALTLFLVVG CSSWYWHCLA SCSLALFWQQ CGFFMHDFMH SQGFHERKID NWIGLACGTL
GVGVNSFWWQ EEHYVHHALT NTVDYENGFF DPQMKEESWA QNKKLFPFFT TRLQRALIAI
QHWTFLPICI IVGRPYIVIA AIVSERRPIV WLALILHIIW VSVLLCQLPT WTQVFVTYSL
ASMLEGILHV QLLVNHYCKP FYERKEVCEE TNWYRMQVEC NINIKNPVWM DWFHGGLNFH
IEHHLFPLMP RHRFREASKH IKAVCARLGI EYDECYWTTA LVRTLQQLKN AAVVFSLDPR
//