ID A0A267GFS4_9PLAT Unreviewed; 1389 AA.
AC A0A267GFS4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig002001g6 {ECO:0000313|EMBL:PAA84846.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA84846.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA84846.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA84846.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA84846.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA84846.1}.
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DR EMBL; NIVC01000359; PAA84846.1; -; Genomic_DNA.
DR STRING; 282301.A0A267GFS4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.506.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 439..472
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 463..601
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 663..857
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 177..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..909
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1065
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1183
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 152685 MW; 2495EA4ADA04EC5E CRC64;
MDRLSLGFAG WLQTGEMEAV LEQTLCVNCL PITPAWTPKF CIVLVKFRLF FCFRTEEAAE
QFLAAQSPPL ALGWLARLDG GPAAFFRFWR SPSAGARTDN DRCGLGWLEP LESSCESTSD
AGAKFDASWR RSSVQLNRPQ EQKTGSRIKN LFRGISMKRT KSATKLNEAR HRVANQPMAV
QQQQPPQAQP QHPAIVPGMR QDFSDSFLSG GYYGYQGYPV SQQQLHQYQL MQQQQQQQQQ
QQQAAAFYLD NGVDMSGGSS SNSSSSRPAQ LQMRRSLSAG RLSRNQALMA EHQRRLQQLQ
QQQQQQEQQD RRRYPQPGAG RRLISSCMPI GVANANDDSD DADSQREDAE NFIINNNINH
MAVGNRCFVE IAAGQAAQDG GLRPAQSHES LLMSPAGPQQ QQPPQSQQAP QPLPMGPSTE
VRGLHQSLMP GLPVGSASFA ISNNPDRVNR YFAAQSQEEA RRWQDGLRKV SRPDLDNTRH
RENSLKLWIF EAKRLQSKKS YFCEISLNQV LYARTSNKEK TSDSDPFWGE AFEFSNLQDI
SLLTVRVFKT QSERKKKHRG QQQPQILQQQ QQHRKNRLVG ELNIPTHEIL SPTERWFDLA
PASSSASSSG SAASSAPAAI RVKARYLSVD VLPLAWYSGL HDCLLRDHCL LAACLEPRLH
VRVKEDLASC LVALAHRRGR AHSLVADLVL QELEPATGPA GAIAGIDFRG NSLATKSVEH
YLRLVGSRYL RQVLSEPLSM LLRSNDCCEV DPLKVSGPAE LAANQRSLCL FAELFWSRVA
SSLDRLPSDI RRLFACIRQR QRRQQMCDTL VSAGFFLRFV CPAILGPSLF GLCQELPGPR
AARALTLIAK TVQNLANGAP FGGKEAYMSF MNRFLADHAS SMRQFVRGLT APPPQSPTPP
PPPPAAPPQA SLSSSSSSVA STDAASAASA VLVDAGFELA QLHCLLSAAL SQMEQAEPGL
LARERCLAKV AAHLAEVTRC LRFNCPPQQQ QQRPQKQQQQ PPPEDWVYSN ANEYDSDLQQ
QQQQQKQQQQ KQQARTNRKA NSRHQRPPPP TESLPPPPPP LPPAATAAQA AAAAKCSPAS
VQEDWQRVLE AARAAVTTAS TTGSSGYQSC RTAPSPVQFL NPTYQKAGSG HLPTLQSRPS
SASSEAAAAA DIETAEGAYD IEADDEVGID DNEAAEEDEE EVPVAASPSP RCSPLPADDV
GEEVGDCSDE LIDEQRDRQL AVEVAAAAAA YQRQQQASAT STSTSTKASA ASTASATSST
AAGQQQQQQP RVRMGVSSVS AYRERKQQQQ LQQQPPPSAD YESELSQLHL ELLHTRQRLE
ATEARLRLNE QEKLQLIADA RQRVGESQAA AAATADPMDS QLQHQQQLQA ILDRLNSLEC
DVRNGQQEC
//