ID A0A267GG53_9PLAT Unreviewed; 1489 AA.
AC A0A267GG53;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=BOX15_Mlig002042g3 {ECO:0000313|EMBL:PAA85045.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA85045.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA85045.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA85045.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA85045.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA85045.1}.
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DR EMBL; NIVC01000350; PAA85045.1; -; Genomic_DNA.
DR STRING; 282301.A0A267GG53; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR CDD; cd00064; FU; 4.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 6.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1489
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012108316"
FT DOMAIN 926..1196
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1200..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1424
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 960
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1489 AA; 162109 MW; D6278C7EDF9DB685 CRC64;
MLMHLMALCL LLPLSAAIDT AAVNASSEYV VCTGTLEAEQ TNEDSVRKFK ALRDRLSGCQ
FVIGDIHLTR IKQEHFDEQD EVLDFGFLNT IKEVTGCVKL VDSCFSSPLE FESLQVIRGT
GCGNSSLLLQ FDSNCALQTP YVAFPNLRHI GGGIILYNVS SCYIERHVSF SELFAYPMAP
VVSRIGQCRD LDNACHSNCT EWPEDGQQHC WGPELRHCQP RTRCRHLSTR DCPYQRCFVD
SQGGERCCHE QCLGGCFGPL AQHCLGCRNF DRNGTCVQKC ELENYYHPGA AQNLSPVEGK
MLPHGPVCVT KCPGSYFTED GSCVKKCMSE RKPDADGVCV AVDESRVCEI EVGALSTICH
SGNPLMQGLT NASMLCTEFH GSVTVNPDCF SDEPKPGKVT VEQLYTMFSR LRVVRGEIQL
LLFGYNQLRN LTFLSHLERV DDRPGEKKSG RIMIVAPEIH FFGLASLRFI NKYIMFLALP
NGSSVSLCTG FIPKQDAVNE SLIQLGASTT SNWLRSPEGL DNIRVRSICP IKPDSCDPQC
EPRFGCWGPG PTNCVRCRSV KAGRICLQSC ESSPGWFLVN STKLLEKQGN TTLELMCSRC
HHSCAKCDGP GPSNCTACLN GTFLDGSVCV AKCNPETQFE DVSARACQPC PKICTSLGNG
KPTCTGNKTL VGPGGCQFCQ HVVVTQQSEA DFTPLLKCGP SSCPAGFYTA LVDFGSNQFN
NFSDFLAVKR TVDLPVTMCA KCAPHCMTCK GASNKCTACR HYSIEPVLTD EFECETRAEP
ACRDGFYADH GNQTCRPCAP PCSTCSGPGE GDCLRCVAPK YLVLAESEDG PVDVENSTSF
CTDTCPEDRP RLIASKRGLI CTAALSTSMI GVLIGAAGFA VSLAALLSFC CIWRRRRSVM
LPEEEKEELE PMLNRGYLAT ISENELARGP EVGSGAFGTV FKGEWTPADG DGRKTTVAIK
ILADSGDNGL SSELLEESRI MASVDHPHCV RLVGICMTQP LQLVTQFMPL GNLRDFLRAR
REPGQIGAAQ MLRYAAQIAS GMAHLERCNI IHRDLACRNV LVSSSRCVRI TDFGLAKALD
TASQEYQASG GKLPVKWLAL ESLISRRFTH KSDVWSYGIT LWEIFTFGEP PYPNVKPQDL
AEYLEKGERL PQPAVCMLDV YMLMIKCWML DEHHRPTFDE LEANFTKMCS QPERYVYNRG
VRHPSHCSSS RVSGNSRGGS GGGGPKSPRH SNNNRQSLDE LDDAYVAMED EVAESDLDND
VFVVDQSTLN TSTTSTACRR LPLSPQPLLY PSVHQNQHRQ LLPSAPPPPE QQLSQPPPPP
PPLMKPPQRS FSVTSGGRRR AAGPPPPLVS SSPQNQYTMD PCQPGPSNSD YYLQPVCLSA
GSRRENPLPL PPRLSPVATH PLATTPTRPP LPPPLPPPLL PPLLQSAGSP GAVANPEYFF
HYSGASTATA AADAPSGGAA NAATAAATPN PASSNDSGIA SPKFEFGHD
//
