ID A0A267GIK4_9PLAT Unreviewed; 1993 AA.
AC A0A267GIK4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=WD_REPEATS_REGION domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig016715g1 {ECO:0000313|EMBL:PAA85883.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA85883.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA85883.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA85883.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA85883.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA85883.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NIVC01000302; PAA85883.1; -; Genomic_DNA.
DR STRING; 282301.A0A267GIK4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 30.
DR SUPFAM; SSF50978; WD40 repeat-like; 6.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 3..46
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT DOMAIN 372..459
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 402..436
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 671..717
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1084..1126
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1389..1431
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1728..1759
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1957..1993
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 613..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1993 AA; 217338 MW; 74E9628D4A787F2F CRC64;
MSSLPTNHLR LEWVYGYRSH QCRNNALYNA RDEIVYFVAG VGIVLNAEEK TQRYFLGHDD
DIVSLVLHPQ KILAATGQVG KEPKICIWNT TNSEVVSLLT ANHQHGVGIL SFDSTGELLV
SIGLDPVATI TVWNWQKGKI VSTNRGHTDR VFDCQFSPSD PNLIVSCGVK HIKFWTLSGN
SLSSKKGIFG KVGEIQTMFS LAFGPGGTTY AATMAGDIYV WNGNNLERVL AKMHSGPAFC
LTSCDAGFAS GGKDGCVRLY DSQMQPLSVI RLADTPAGYS GIAVRSVDWR GSAVLAGTQD
GEILEIGTEQ LDRPAVLVQS HSEGELWALA PHPKKPVFAT ASDDQTLRIW HAGNRDCQQK
ARLDRKARSC AFNEDGSLIA CGFIDGGFTV FRTRDLVELF SAKERKEVLH EMKFSPDGKF
LAVGSNDNFV DIYDVQQKLK KVGECRGNSS FITHLDWSED SQYIQTNSGA AEHLVFKAPA
GKQVVRAAEI ETIKWRTWTG VLGDCVKGIW EKYTDTNDVN AVDVNFEHEV LATGDDFGLV
KLFRYPSTRK GSNFRRYVGH SAHVTNVRWL QDGCTLVSIG GADHAVFQWR LVSEGGDDVA
GVGALTDGVG QSSAYLDSGS EGSDTDSSAA GGLDSDVEAE KQVNYDRFVD KAQLASGLKA
SLQAELPAGQ KRKRAPDHGL KLDFAHGYRA YDCHRNLFYA QSGEILFNVA AIGVVHNKET
NTQRFYTGHT DDILCLTVHP NADIVATGQV GKDPTIHVWE VESLKALSIL KGQHERGVCA
VAFSGDGRKL ASVGLDDNHC IVVWDWRKGE RLATTRAHKD RLFVIRWNPH DPNKLITVGV
RLIRFWTVAG AGLTSSRGTF GSVAKLDTML SACYGTDAET AYTCGASGLV YVWQGNVLSR
TVKAHEGPCF ALEFMPGPKP CFVTGGKDGN VCVFDDALER CARTFNLRNS NMGRGNLGVL
LEDNPTVRSV MPGRNNTILA GTLNGEVVEI EKDGPLRVLV QGHRQGEVWG LAAHPTEPIC
VTASDDRSLR VWHLDGRRML ACRVLPQPAR CCDISHDGRL IGVGFRDGSF QVLNFDSLDP
VVTLRHRKEE ISDIKFSPNP GKYLAVASHD NFVDIYNVAT QQRVGVCKGC SSYVTHIDWD
ANGKLLMVNS GAREQLFFEA PRGNRQVLPK ADIERLPWHS WTCVLGDTCE GVWPPKCDIT
DVNATSLSHD RTLLATADDF GLVKLFEYPA KGKFAKYKQY VGHSAHVTNC RWSFDDTRLM
SVGGADTALL IWRHCDQTER RVAATAAAAA PLSGTAALPS DDSDTDSEEE GGYDSDVERE
KRMDYASKTY QISPLRERVG KRPTEQQQAG GDGLDALRPA VSRKTPKPPK VVRGVASGDK
KRPHHQHEEV ADLQLEFVHG YRGFDCRSNL HYLNEAGDTI VYHAAGACIV HQVSAGTQSF
FLGHDDDILC LMVNRVPKFA GVVASAQIGS ADPPILVWSS RTLATLATLR GAHSVGVCSL
DFSASGKHLV SVGLDSQHTI AVWRWQEGQL VTTCGGNSQR VFRAEFRPDS DSQFVSVGVK
HVKFWTLAGS QLVHRRGQLS GYADGNLRMT TMLSIAFAHN GVTYTGAMSG DVFVWQEHRL
IRLVEKAHQG PVFSLYTTLK DGLIVSGGKE KGGKSGGGLV KLWDQEMKRC REYNLNLSDK
TAVIKSVCRV RGKILVGTKE SEIIEVGEKD GALTQVARGH GEGELWGLAV HPGARQFATA
SDDGTCRIWD IGKKTMLHKL HSGPARSVAF SQNGEMLAAG LKNGSVLLLN TASLKLIGKR
RDRGSVVSDV RFSPDSKLLA VGSAEGAVDF YQVGGPGGLS RLGYCKGLEA AVLQTDFSAD
SAYLKVTSAS YTAQVFTAPA GEPVTDPNFM ESITWQTWTS IVGPEVLGIW PKSATKGDIN
CAHLCHCGAA MATGDDFGNV KLFAFPVTEP EVQHKTYFGH SAHVTNVRFT YDDSYLVSVG
GDDCCVFVWK CKP
//
