ID A0A267GJS9_9PLAT Unreviewed; 728 AA.
AC A0A267GJS9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Nuclear receptor domain-containing protein {ECO:0000259|PROSITE:PS51030};
GN ORFNames=BOX15_Mlig004368g6 {ECO:0000313|EMBL:PAA86295.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA86295.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA86295.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA86295.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA86295.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA86295.1}.
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DR EMBL; NIVC01000284; PAA86295.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GJS9; -.
DR STRING; 282301.A0A267GJS9; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06916; NR_DBD_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF473; STEROID HORMONE RECEPTOR FAMILY MEMBER CNR14; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 54..130
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT REGION 24..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 80562 MW; E1FE6DD45F6CFE25 CRC64;
MTSSDCLGLL AVMEATAGED LCAPAQQQRR RREQPAQEQQ PSSSSCSTMA EPPLSRCAVC
QDVASGVHYG VPACEGCKGF FRRIVSSRNL GGSCGHIIPI EMTPQTRNTC QWCRLKKCCA
VNMGRERSKL GRRAKGTRDQ PVAAASSSVG SSTDCSTGIV EVPDNGPILN EIPLPGHSPV
TISAAAVSSS PGSSHQHISS ASITDSQLML YIEQKRQEFE QQLSRRLGAN GIIGPAFSHL
KRSPPSDLHS FASYSPMQPP PPLKRQRGGS ASAAIDFLEL DQPPGYNNLN NYQSEQVQFE
QQPNAHHRQQ QQQQQELGRA PKKVWLQKSL LPEVLPLAAL QTGESVASHC QRLVGPLLTQ
ALTTFVQRAT FDEKVTNLLL TGIEQFYAHW SPTAATMPGS MVPLITDNIN LILAGHRRSF
QFSPERMAQF RAERLHLTRE PLADEEPVVI SRLHACLPSI LNRVIGFAQS IFNDSKFTVS
VSSTPSAVQV SNVDTKICAE DKRHLLLSHC SQLVAMRFCF SLVKRQEGYI IDPTMNFRLT
RRFLQSARHP TLSLLFTRFF DVSARWDSLA MTDSELAFLS AICLTSPYMG TRPESAFANL
NSVVSVHLSI VGLFWTHLCN EEARRHDWSP ELLQQSHELR LSVRLAAIKR LFRLAAVFSL
LLDINSLSSD TFVLMESQIN RIAFCDEDSS SLGESSGSSE ILLPKGVSSG QFRQLPQHQQ
QPHLQNWW
//
