ID A0A267GQG4_9PLAT Unreviewed; 938 AA.
AC A0A267GQG4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=phospholipase A2 {ECO:0000256|ARBA:ARBA00013278};
DE EC=3.1.1.4 {ECO:0000256|ARBA:ARBA00013278};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig020039g1 {ECO:0000313|EMBL:PAA88280.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA88280.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA88280.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA88280.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA88280.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA88280.1}.
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DR EMBL; NIVC01000197; PAA88280.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GQG4; -.
DR STRING; 282301.A0A267GQG4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047148; PLPL9.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR24139:SF34; 85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR24139; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 364..396
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 584..775
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 502..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA88280.1"
SQ SEQUENCE 938 AA; 102785 MW; 605E57789BFA5798 CRC64;
PSRNMLNSLK NYVNTQLSTI NPYKIEEANP ANFNKYQVHI SDNAGSKLYR VANHFEMIFT
YTNAKNESKA YSLFRLESMS DAETLFAHYS SRLRVLERVE RALLTRKKDV ESACEVLRQN
PGYTACHVAV HLNWIHMLRH PDMVATVNSP DDVSRITPFI LSVVNGNMSI VREFLTMSNV
DLTIVDSNGD SVFHHAAGKP SELMTLLIGR DQTMVNHVND EGKVPLHLTC QAADDLGTLL
LLQAGADPAG GEATCPAKPI HLAMRSCSLK CIEMLCTRDH GLINSVDSDG NSVLHYAREK
EITYTLCHYP QINKNLVNTK GETPLHSVII EMYKTTDKKK KEDYLDVIMT LLVLEADASI
PNIEGETPLH SAVRTRNVDV VRALIVFEAD VNCLNKRGQT PRHILSSEEE GQPAFGILPY
FRTSTRDRDV LIYTLHMVGA NRCSSSTSGC GDGCHYRGKN NGTVPEACKI PELESHSPEP
APKSNPLSGA SAVALLKRLD SSRSSSGGVN FRNSSSSSLN SGGNASASGG EQQSPSEPCV
YLAESASSHN ILANATTASV DVPDSSESDD ASLALDNAEG DTLLCLDGGG IRGLILAQLM
RAIERRLIQH EQQPQAQLVD YFDWVSGTST GAICALALGV GKTAAFGRCL YLKLKDRMFQ
GSRPYAADFL EQTLQEMFGE NTVMTDIPLS RCGIMVHALL ADRFPPLLHT FRNYDPPLPD
PKPLKSSPEV AVCRPEDQLV WRAARSSGAA PTFFKSCDQY LDGGLVANNP TLDALTELTA
YYKKNYNQLP KLRCVVSLGT GRIPVIPISN RDVFMPSNPA QLLQTFRGMN SLAQIMVEQA
TSADYQTVRR AQAWCDCLGA RYYRLSPPIS ADIPLDCKST SILIQMLWET EVYLARSTDK
LDQLVRVLTA PHRAAKAAAT FSAEPGTPGT PKTPKVAD
//
