ID A0A267GQQ2_9PLAT Unreviewed; 802 AA.
AC A0A267GQQ2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig027573g1 {ECO:0000313|EMBL:PAA88355.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA88355.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA88355.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA88355.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA88355.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA88355.1}.
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DR EMBL; NIVC01000195; PAA88355.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GQQ2; -.
DR STRING; 282301.A0A267GQQ2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 391..594
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA88355.1"
SQ SEQUENCE 802 AA; 85809 MW; 308A4D968A1C4202 CRC64;
PAAQRMASFT PHRGGRGGGG RRFFRNSWRG GFRGGNRGGT RGRGGAGGGF HSVMGAAGMD
EDEAPQQQSQ QQQSSGLVLE APAGVEFPGW SLYFPRLRYQ AGLAQVRLTR AFLAFLGRYV
DECGVSLEAV QDAGGLSVPS QQLLEAPEPQ AEVANFAEDL VAQPDTYLAC LHLALHSLVC
RHRAAAQQSP PSVPLLHCRI GSLPELTQMQ DLKARMLGRL VSVRGTVIRV GAVRAVCRRL
AFQCEACATV CVLALDESGR FAAPAQCSGG CRSRTFRPVR ASPLTRTADA QTLRLQETTV
DDQGRVPRTL ECEVSHDLVD SCAPGDTVTV TGVVAARAAA EDRCVLNVML RVCALHSDQQ
RRSAPGDAMV DSEFTVKELY AIEAMHSLPN VFSTLVASLC PAIFGHESVK SGLLLALFGG
SQRGGELGVR SESHVLVVGD PGLGKSQMLQ AVASVAPRSV YVCGNTSSTA GLTISLSKDR
GSNESGLEAG ALVLADRGVC CIDEFDKMAK QHAALLEAME QQSVSIAKAG VVCSLPARCS
VVAVANPVGG HFDRARTVGE NLRMSAALLS RFDLAFILVD RPDRRLDGLL SEHVMSLHSR
AGSSAGSSVG GVSAAMAAAA GGNPVPHALM RKYIAYARKY VQPRLTREAA AELQKFYLEL
RAGLRCRDAC PVTTRQLESL VRLTEARARA ELRELCTAED ARCAIQLTRD CVRDLLSDDT
GAVDVSRSSG VSCRSAAKRL LQRLQRAAEQ RQNRLFSSEE LMQHVRSLGV STDATALLQA
LNSQGFLLQK GPRLYQLQSY DF
//
