ID A0A267GVU8_9PLAT Unreviewed; 1031 AA.
AC A0A267GVU8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 22-FEB-2023, entry version 9.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN ORFNames=BOX15_Mlig024153g1 {ECO:0000313|EMBL:PAA90125.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA90125.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA90125.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA90125.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA90125.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA90125.1}.
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DR EMBL; NIVC01000126; PAA90125.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GVU8; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 2.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR36902; -; 1.
DR PANTHER; PTHR36902:SF1; -; 1.
DR Pfam; PF00024; PAN_1; 1.
DR SMART; SM00473; PAN_AP; 3.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1031
FT /note="Apple domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013034990"
FT TRANSMEM 983..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 708..789
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 1031 AA; 117323 MW; A7983B9D27427242 CRC64;
MAIRQLVAWI LLALAVISCQ FCGFANGEFC QKVNTTEGVG LPYIPPSYQT RIEMNILTKN
QTYEFQEWFD GYLGNVRIRR YQKNGEIDDY IYNNATREIY VIFNDLVCLV INMTGKTDLD
LLFGVDGRLL PSSALMLRFS KEFGMEYRNR SIVRGITVDY WYSCQTWKER KAVFEVHWYF
SASSWNTPYD VNLPVRAEVI GEAGDVSNPR KFHMIYDFVS FRDVLMAENT IFDTPTGVYC
EDRMQVQKPP ELPAVMSYTQ EMLVHDPALE MVQYGNVYYD GSQFLVKYQF RDPNGDTKPP
FYNPGSMTVI QDFTTGISYF IDDLIGNCTD KPISNDFFDT EDPPIKDRPG WDIIELRSPK
DLFRIDETYQ FTGKRVVRGI PIHRYISLRK DYEIKGRPGM NFTFEYEMLD PRVSEVVLGK
NKINQGKNIP VQLRITNYNT LGQIDDPTFN YQEVYNFYNF DTQVEPDAEK DFDQLQPYDL
DVTQCYSKAE RKNILIRFLN GGIYDKYVKG SQNLFIRRAT KVLANADLGF VNPIRFQRVR
LDYDDVFIYL IFTLLDGPHP YAQFNRLTGP NRYIESAEQT ANVASELDCL RRCNSFLMPP
CNSVAFCPGS KSGSNCLLSS SFKKDTENPD KTHQCSVLIR PVSVIRPDAL ELSLETAFDL
LVTYVDSSLF RVPMEKVAPE TGNIDIVNIT ALDIEQFEVR PNVDLALTGR HLFQFEVTKS
AGMPPTRAML DALSVDDCAE ACLGNADFEC KSFTYCYSLG QCLLNDASPR EQPDKVVQRG
LCNLYDKTEL GLFTKEPGLS RLIDVHKDLQ LVDTERECAA ACVGSSPSKP CRSFDICDFG
EGLKKFCYLS ASHKSDDSVK SEPNLNCTHY SRSFTTDFKQ QFKVSQPDLS AYTATFSDLN
LDYCSRRCVE DYGEKCNGFY YCEPYNGNEV RSTCSIRVPG VALVTKPSGS SGVPSCAYYS
REYDTDGSIW IERNDSVNPG DTIGLSAVAT VLAVLGILLV SILVGMGFIG IYLYCKNRPL
QMEEPEVQFS R
//
