ID A0A267GXJ7_9PLAT Unreviewed; 667 AA.
AC A0A267GXJ7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=LTD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig006039g1 {ECO:0000313|EMBL:PAA90761.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA90761.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA90761.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA90761.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA90761.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA90761.1}.
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DR EMBL; NIVC01000104; PAA90761.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GXJ7; -.
DR STRING; 282301.A0A267GXJ7; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF11; LAMIN DM0-RELATED; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 103..485
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 520..640
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 369..467
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 74419 MW; AED7BC0953E84595 CRC64;
MSSKSGTTKR KSERVRTTST TESEASSAAA AAQSEVSATT VSPQKVSGST VTTTTTSSRK
VTKSSLTGAP TVGAASGEPS TSGGAAGARR RSRSPLAISR EQEKEELAHL NTQLACYIEF
VRSQQQSADT VRRQYETLSE SMTHEREESS GLYEREINGL RHQLDKLAGE RAALQLALDK
ANGERAEADK RAAGLERTLK EQERQLDRLA EADTEARNAR ADADRLRSQL AAAEKEAASV
AKELAAARKG LANAERNERD AKRLQAELND SQAQLKAMRD QLETEVKLKT ELENRVQTAT
EDAAFKESLL KEERSRYQER SVLIEEVSRV READFESRLC EELRHAREEA DQAAAAFRLD
LEATFRVKMD ELRSASERYS QDARASRDEI VELRRRLHDS GLELEKARKE ADLLRASNAR
LESALAQERD AFEQQLDYLR QEEKRNRERL AEQLEEYNNL LTSKLALDQE ILAYRQLLDE
EQRRTNYSPH KHSNPSDASS PFARGSKRRT ADFDDEELYS SMAYTVHQEQ CGAIHVHELD
PERGQFVRLR NTSPDSEVAI GGWTLRLECD GVTSAFKFPA KTVLAPLAEA TVWSSDAGVA
HNPPADYVSK TKACGQGENI RVRLVDGSDK EMASRHMQLD RTKLAAVRAG KRMRRGGAES
SDRCSVM
//
