ID A0A267GZJ2_9PLAT Unreviewed; 691 AA.
AC A0A267GZJ2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAA91425.1};
GN ORFNames=BOX15_Mlig016834g3 {ECO:0000313|EMBL:PAA91425.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA91425.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA91425.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA91425.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA91425.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA91425.1}.
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DR EMBL; NIVC01000087; PAA91425.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267GZJ2; -.
DR STRING; 282301.A0A267GZJ2; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..691
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013080117"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..149
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 243..530
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 148..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 77..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 108..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 691 AA; 76510 MW; 8CAE163CC218210F CRC64;
MAHLPLLLLI LPALLPSPTA SVGIDFALHR CEPIAVEACQ GIGYNATTKM HNLAGHAEQR
DAEVLVRSFM PLIHYKCSAN LRFLLCSVLT PMCDPKWPKP IGPCRPLCQH VRSRCSPVLA
DFGFEWPAFL NCSRFPLSNA RGDDMCMAGS PEVDPEEDGP AGEPVGRPGR GGGSRGGSGG
AEPAEDWRLN LEKWLHAVRT QSFGPDCGHM RNREQYVYIN QTADCLLRCG AHDLFSQDDK
RLADAWVAVL ATLCALSSLL TIATFLMDRS RFKYPVRPVL FMALCYLCYS LSYFVRLAAG
REAASCDRDQ LSGSSVLIRH GLDNTNCAVV FLLQYFFSMA ASTWYVMLVF TWLLQAGWKW
SPEAVARKSC YFHLPAWVVP VCLTVCVLIV RKVEADELFG MCNVGNQNSH TLLSFVIVPN
VVFLALEVIF LLAGFVAMAR VRRHVKSDGQ KTNKFDMLMG KIGLFSALYV VPNACITAFN
IYDYSSRDLW HVPGSPYRPS LAVFLIKVFA SLVIGVTTIL WIWSAKTLQT WRRLLAPWSA
SSSATASAAQ RRGDRGSSGI GGGQYPKLQY QPADQTDSVQ HRQVQHQHQM SAMQHHQQQQ
QQIPLAHQQQ QATQLMMQHV QQMPTQHHSG GRQPQQPQPQ PPSSLASGSS PGWAGGSGGK
QPMVTAHFAG ENKVKSFPNQ QQRDLPESTF L
//
