ID A0A267H276_9PLAT Unreviewed; 1063 AA.
AC A0A267H276;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig026670g2 {ECO:0000313|EMBL:PAA91629.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA91629.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA91629.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA91629.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA91629.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA91629.1}.
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DR EMBL; NIVC01000083; PAA91629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267H276; -.
DR STRING; 282301.A0A267H276; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF4; FORMIN-LIKE PROTEIN; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 53..434
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 574..993
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1025..1053
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..570
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA91629.1"
SQ SEQUENCE 1063 AA; 116913 MW; F15D2224368F3F0E CRC64;
RCCLGVGGAG QKPSTSSNAP DEDIVHSQQQ LHKHFKSNSQ IGGLNLANPD DLVRPESEEE
VDRCFNEIID DLFDSAEAKE KAASLPLEKK WQLYVVYQAN DNSNSENKNQ LSVYLYYLKL
MSQRMVVDDS PARLLDGLAA SLRSQPISFV RAFLDGGGLD ALAEVLAIDS YDDAIAVSLL
RCLYCAMNSQ LGRDAVSEHP SLADSLLGAL VTKVNSHAKL YASNMLAVLA LGPGWHRVMR
AFDRQAIAGG RRFHLLVREL AWAVSVDLAV SLLALINALL HCAPPTHQTT LLRASSDRSV
DQHLRQSQLR RRLLLRADLR RWGIDQLLAE SPHRQAPNFA RQCDAFRSLA ADDAAEMAAW
LSESTPDSND LASTIEMLDD GCHGRAMLES CGLMLAERRQ ARLRLAALMM EQLCQQPAAD
IDYPDVVDVD EVDGTVDEND STIRLLPGLC VNRVERRLEE LETELGKLSE QIDELRHRGQ
LMQEDLEAGK RSLAGKDQLL EAQAMEIDRL RETVKLLESR MVTKDKTDAT SSSAPPAPPP
APPPAPPPPP PPPPPPPPPP PPPPGGPPAS GTAAPKFARP RVRVRRFHAP LLQSEPGSDS
LWSRVSVEQA ISEINLRDIE RAFGDKPTAS DDLADSENQL SADGQQGQLS LLHQRMTDNQ
PPATSQHLSQ RSSTSYAEIL SPERRKALEI LLQSLRMSQI DDQKLIEAVT SMDAENCLSG
HLCQQLLAVA MPTQDEAAQL KRAASAKLPL GQAATFMLRL SSAPQFTEKL RALAFRHGFA
EKSIDCRNHL ALLSAACRQA LESRALRRLL TLTAALAALL GPSPNQALRG VRVSGLSRLL
DARTTGTSAS SKAASTSTCS TALHFLLAFD SSLMALPSQL QKLAQAARSP TPRELAEEVA
SLSSAFTDAV RAQLAPETGR QISAELRSLK SALTECQALW DQLHRYLAEP QDDPTLLQEL
ARFVREVAKA SHQMKLEQQQ QTRRQQQQQQ QQKQQQQQQR LSSQQQLQKQ TMQKKQQQQQ
QQTHQQQSEG EMDDLISALQ SGNIFAARRR TRIVVPPSND SVA
//
