ID   A0A267H494_9PLAT        Unreviewed;       665 AA.
AC   A0A267H494;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=MFS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BOX15_Mlig002798g1 {ECO:0000313|EMBL:PAA93086.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA93086.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA93086.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA93086.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA93086.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA93086.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NIVC01000033; PAA93086.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267H494; -.
DR   STRING; 282301.A0A267H494; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR039672; MFS_2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11328:SF24; INNER MEMBRANE SYMPORTER YICJ-RELATED; 1.
DR   PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13347; MFS_2; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        151..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        438..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        521..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  71642 MW;  1883A6637C962319 CRC64;
     MPPYPHRHHS SPKMRSHGQP FSNESAMELN EENGAQPSAI PSVATLTHSN TMDPLITSNQ
     SVYPNLEVNV MEVPALSTCR RLLYGLAAPP SAMCGNILGF LMSVYLLEVA KLSPGLVLTI
     SFAGRFWDAV SDPLIGYLVT RTKTRWGKCR IWVLGSAPLC ATSFILLFHT PSWQWTPGRF
     IYYFVVYFAF CTFLTTYHIP YTAMTMLISS RTVDRDAATT FRMVFEMVGT LFGVMTFTFI
     TQVGPDRCTL ASASGNSHSN GSLLSSNQSA PATAHVSPEE EARYRLGASI IGAVVLLCGG
     IGFFGTKEIA AEVKQAKPTL GNAVADSNSD SMLATFRSCL GHRPYRLLML SFMLSSLAIQ
     TVQNSLALYT IYSLKMKPHL KFAIAVVMVT AILVTPLVFY LIRRLGKKRV FIIGLALILP
     VCLSATFCPA RVQFVPQYYA TMVVAGCYVS INMLLPWIML PDVIDDYTVS TGRRDEAAFY
     SLYVFFNKFA VGISTACLQL GLHLTGYQLP PSCHQPEMVG YALRVMMGPL PMLLVVAAFI
     VLRLYPITPE YRRNLDKRML KAAQLDGLPM NLNSLDYLGS SVDPLAASGN VASLQSAAAE
     AADGDSNGGG GPSGSGIVGC CLHPGGGDSG CGGSDSASDP DGVCRKKRLS SSSSSSQSGG
     AAAVC
//