ID A0A267H549_9PLAT Unreviewed; 224 AA.
AC A0A267H549;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Homologous-pairing protein 2 homolog {ECO:0000256|ARBA:ARBA00016093};
GN ORFNames=BOX15_Mlig011476g1 {ECO:0000313|EMBL:PAA93396.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA93396.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA93396.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA93396.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA93396.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HOP2 family.
CC {ECO:0000256|ARBA:ARBA00007922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA93396.1}.
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DR EMBL; NIVC01000029; PAA93396.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267H549; -.
DR STRING; 282301.A0A267H549; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR010776; Hop2_WH_dom.
DR InterPro; IPR040661; LZ3wCH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15938:SF0; HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR15938; TBP-1 INTERACTING PROTEIN; 1.
DR Pfam; PF18517; LZ3wCH; 1.
DR Pfam; PF07106; TBPIP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT DOMAIN 9..68
FT /note="Homologous-pairing protein 2 winged helix"
FT /evidence="ECO:0000259|Pfam:PF07106"
FT DOMAIN 161..217
FT /note="Leucine zipper with capping helix"
FT /evidence="ECO:0000259|Pfam:PF18517"
FT REGION 70..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 224 AA; 24980 MW; 7073FF917E8DAA30 CRC64;
MATSSNPDEK RVLDYMRDAN RPYSVNDVFS NLHKAVGKTA IQRALDSLVS AGLINEKTYG
KQKVYVVKQP TASSSNSDGS APTNALPDEA EKRDLETRAQ TAERELVVEQ AEVKKLQREL
ATLRQRPTCE QLRARLAELQ AELAPKTERL AAIDSGEGRK VTPELMSDAR KIRANLVSEW
RKRKRACVDL IDCVLEGYPA SKKAFFEEVG LETDEEHNAV VPKV
//
