ID A0A267H8E1_9PLAT Unreviewed; 1242 AA.
AC A0A267H8E1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=BOX15_Mlig004030g1 {ECO:0000313|EMBL:PAA94536.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA94536.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA94536.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA94536.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA94536.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA94536.1}.
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DR EMBL; NIVC01000007; PAA94536.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267H8E1; -.
DR STRING; 282301.A0A267H8E1; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 580..601
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 631..652
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 664..683
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 779..797
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 817..836
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 870..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 910..926
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 970..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 995..1015
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 153..413
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 517..1048
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 135251 MW; A760E307DAE1473D CRC64;
MSDEPVPDSG RYAGYGLSSD ERVADEVSSH RRIPAGRPTA VLVGVRLPQD DDDKGGDGKT
RKKRRRRERL RRGSTSIDEP DGGAANEPAP DPNSTDPSAR VQFLLGNLDE DGETGEESEV
HPIFCEMDEL FKSDSAGELQ WRETARWVKF EEDVEEGGER WSKPHVATLS LFSLFEVRNS
IHRGEILLDC EGQTMEAISD LLTERLVHAG KLSESLRPAV AEVLLKRHSH LYERKARGGS
HLGAKIRSFA DIGRKFSSKD LEKDASGHAL GSRGDLAAGE SPEPADLHHS GSGHKFDQHF
MKKVPPGAET SNILVGSTDF LDRSLTVFIR LRHAVILGDI TEIPVPTRFI YVLLGPPGQT
AHFHEMGRSM ATLMSDEIFH DVAYLARNKD DLLSGVDEFL KSCTVLPPNE WDPSIRIEPP
KEVPSQEPRK QGSLVNAASA SGGLGSDHGG VEDTHVSGGS SGGHGAPGTS ASAPADSGES
GTGGANGSGS GGGGGGGGDG DAEGGHGSDP SLTMTGRPFG GLILDVKRKA PFYVSDFKDA
LHAQSLGALL FLYFACLTPI ITFGGLLVDA TEGHLGAIES ILSGAICGTS FALCSGQPLT
ILGSTGPVLV FETIVFKMCK DYDWDYLSFR MWTGLYISLI LLLFVAFDLS ALVKYITRFT
EESFAGLIAL IFIVEAVKKL LFIGKEYPVN RAWHPTYATK FDCRCYRKST LNDTDWKPLK
PGQHLRLPSY KPNGSEVYYA NYSGFNYWSW NWYETNRACE NNQGEWRGEG CGSYFVPDVF
FFSCLLFIGT FAISYGLKMM RNSCFFPNRV RSIISDFAVM LAIVAMTGAD LALGLHTPKL
NVPERFEPTL GYATRGWLIK PLGNRGQNPW YTIIIAVFPA LLATILIFMD QQITAVIVNR
KENRLKKGKG YHLDLLVVAV LIGINSVLGI PWFVAATVLS INHVISLKIE SESTAPGERP
KFLGCRENRL TGFLIFLLIG LSVFMTPILK HIPMPVLYGV FLFMGISSLN GLQLVQRTGL
FFMPQKYQPD YIFLRHVKIG QVHKFTVIQI ACLVVLWVVK AIKAISILFP IMVLAMCFIR
KALDFVFDQS ELKWIDDIMP PITVSLGRKR NSGDEGGAAS GAPGAASSGR QPITIELDMD
LKQPAATQHF NVSNEVDRTS IWKNLTGAGG NADGGKSSKK QNKRSSKKTS SSSAAGGNED
VGGAGKLDDA DKEAAEALLK MPEIVVEPPS GCNSPERRSS NA
//