ID   A0A267H8K4_9PLAT        Unreviewed;      1116 AA.
AC   A0A267H8K4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-NOV-2023, entry version 17.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
DE   Flags: Fragment;
GN   ORFNames=BOX15_Mlig001958g1 {ECO:0000313|EMBL:PAA94613.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA94613.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA94613.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA94613.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA94613.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA94613.1}.
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DR   EMBL; NIVC01000006; PAA94613.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267H8K4; -.
DR   STRING; 282301.A0A267H8K4; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR037769; Abr/Bcr.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR   PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          910..1113
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          145..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..204
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PAA94613.1"
SQ   SEQUENCE   1116 AA;  120394 MW;  42365586E574F7D9 CRC64;
     AESRMASSAT VSGRDFRQEF DQLHRLEFGS GPDEVWQVLN GSSATAVDQL TALQAAVSKA
     RRQLVEAERK VARQRFLVGF LTDCADRLCS VVGGGSGGVA SSGIGDAGAI GSNGSEGGAD
     CATPLQEYLA DEPVYASVLE LRQQRRQVSS ASQQRPGALP PPLPPKLPWQ QGMPRRTSGG
     HRPPPPPPSS PPPSPPPVPP HSVPPSSWRL DRSSVRYVTP YEESEPASTL TADSAEQKQQ
     QQRQIIAQRV QCEEAFHLCA LRVLAQCCSA VRCAGQRSAS CRPAAELVGE AFYRFDELQT
     AQEAFVRTLE ARLANWSSAS RIGDLYLSLI ECKAVAEYAG HLFASRQAVQ KLASMPEFCD
     LFKVAGGCGG RPVVTVTSPE LKRSEEIGVV DLVSLPARWL VTHAENCKLL AQVTPPGHPD
     LPQLYEFCQR LHRVFSGDAS GCSGGGSGGG GSGAGGGSGS TGGSSEAGAS SASSARCCRR
     LLKQQLMVEL SGNQRKLRRV FLFSDVLICA SQRLLTSDSL GGSLVGLDSA EEVGLQAKWH
     VAKNSCVLFN SERQAPSRAA LEQENRRCQL ENSLKIRIKS LQAEMAQLRA EAGRNASGGA
     TSRQMQRCVD QLRRLQSQLI VTVPNVPLRV GRTQEKQYTL LLSSELERRE WEQLIGANLV
     QQPGNRGDCN PVTVSQAEVA DLLHAYRHVA QDVTDLGNRY LRRQRRQVQQ SMEDGLDCVD
     GGGGGGGETD DARSTISNGA DFTSELDKCE SGLVGMLSVT VHKLEGPAEP ASYCVATEIK
     DVSQHFMRVH STPFCSAGSS QPTFECAFQL SLDGTESAIR FVVSQMDAAN KRPNDIGYLE
     LRLCESGLRD YQAKCHYLSA GTKTLLLTLS LAFVPQYLCV LPPQQQQKVL NKQYQQPQQQ
     QQQHLAVFGV PLETLVEAEK SMLAEPLAAE AVPMLVQGLV QQVNRHLTEL GLYRVSGSST
     DLQSARARID TDGPGPPQAL DGLDIHVCTG LLKLYLRELP EPLFTASLHE ALTAASEADD
     RELLGLLPTG TLPRANAATA AFLFDHLLRV CDSCQVNKMS PSNIGLIFGP TLIRPAITAS
     LTLTALDPKL IGQQSMQQGA VLARLLDLYR AGRLVF
//