ID A0A267T5D3_9BACT Unreviewed; 561 AA.
AC A0A267T5D3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DNA polymerase/3'-5' exonuclease PolX {ECO:0000313|EMBL:PAC27939.1};
GN ORFNames=BWI92_21145 {ECO:0000313|EMBL:PAC27939.1};
OS Flectobacillus sp. BAB-3569.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Flectobacillus.
OX NCBI_TaxID=1509483 {ECO:0000313|EMBL:PAC27939.1, ECO:0000313|Proteomes:UP000215844};
RN [1] {ECO:0000313|EMBL:PAC27939.1, ECO:0000313|Proteomes:UP000215844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BAB-3569 {ECO:0000313|EMBL:PAC27939.1,
RC ECO:0000313|Proteomes:UP000215844};
RA Dhebar S., Dhebar S., Bhargava P., Bagatharia S.B., Soni S., Joshi M.N.;
RT "Flectobacillus sp. BAB-3569 genome sequencing.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAC27939.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NJFZ01000024; PAC27939.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267T5D3; -.
DR OrthoDB; 9808747at2; -.
DR Proteomes; UP000215844; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07436; PHP_PolX; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.10.150.110; DNA polymerase beta, N-terminal domain-like; 1.
DR Gene3D; 3.30.210.10; DNA polymerase, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR002054; DNA-dir_DNA_pol_X.
DR InterPro; IPR010996; DNA_pol_b-like_N.
DR InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR InterPro; IPR037160; DNA_Pol_thumb_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR022311; PolX-like.
DR InterPro; IPR047967; PolX_PHP.
DR PANTHER; PTHR36928; PHOSPHATASE YCDX-RELATED; 1.
DR PANTHER; PTHR36928:SF1; PHOSPHATASE YCDX-RELATED; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF14716; HHH_8; 1.
DR Pfam; PF02811; PHP; 1.
DR PIRSF; PIRSF005047; UCP005047_YshC; 1.
DR SMART; SM00278; HhH1; 3.
DR SMART; SM00481; POLIIIAc; 1.
DR SMART; SM00483; POLXc; 1.
DR SUPFAM; SSF47802; DNA polymerase beta, N-terminal domain-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Exonuclease {ECO:0000313|EMBL:PAC27939.1};
KW Hydrolase {ECO:0000313|EMBL:PAC27939.1};
KW Nuclease {ECO:0000313|EMBL:PAC27939.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000215844}.
FT DOMAIN 1..298
FT /note="DNA-directed DNA polymerase X"
FT /evidence="ECO:0000259|SMART:SM00483"
FT DOMAIN 50..69
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 90..109
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 125..144
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 322..405
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 561 AA; 63512 MW; 095FBA262D97A2F2 CRC64;
MNNQDILDIL ELTVKLLELH DENEFKIKNL SFAVRALDKA TEDFITTPVA QLAAIQGVGK
STASKIEEIR TTGQLAELNE LLNKTPEGIL EMFKIKGIGP KKVRMIWQEL GITDTRELLL
ACENGEVAKL KGFGDKIQES IKQSILYNQS NSGKLRMEKG QEIADFILDI LEPVFEHVQI
VGDIRRKNEV VESIQLVVGH DQPWEVQQLL NATPTLQQNE KDSSPFTWRG NIEGKLIPIE
VIICPEKQFI NQGFIFSASA KHLAKHHIYQ TVQNQTFDSE EAIYAKVGFP YIIPEMREGT
FEFDWIQKHS NDQLVTWDSL KGILHNHSTY SDGKNTLAEM ANYCRELGFE YLGIADHSKT
ASYARGLNEV RVAEQHAEID QLNAQYALGD KPFKILKGIE SDILGDGSLD YDEEVLKSFD
YIVASVHQNL KMTEEKAMYR LIKAIENPYT TILGHPTGRL LLSRAGYPVD HYKLIDACAA
NGVVIEINAS PYRLDLDWRY IQYALEKNVK LSINPDAHEK EGYFDMHFGV ANARKGGLTA
EMTFNAMSLS EIEEYLNGRK K
//
