ID A0A268EA23_9BACI Unreviewed; 647 AA.
AC A0A268EA23;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Elongation factor G {ECO:0000313|EMBL:PAD69977.1};
GN ORFNames=CHH83_06135 {ECO:0000313|EMBL:PAD69977.1};
OS Bacillus sp. 7586-K.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2021690 {ECO:0000313|EMBL:PAD69977.1, ECO:0000313|Proteomes:UP000216230};
RN [1] {ECO:0000313|EMBL:PAD69977.1, ECO:0000313|Proteomes:UP000216230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7586-K {ECO:0000313|EMBL:PAD69977.1,
RC ECO:0000313|Proteomes:UP000216230};
RA Kalinowski J., Ahrens B., Al-Dilaimi A., Winkler A., Wibberg D.,
RA Schleenbecker U., Ruckert C., Wolfel R., Grass G.;
RT "Isolation and whole genome analysis of endospore-forming bacteria from
RT heroin.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAD69977.1}.
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DR EMBL; NPCL01000017; PAD69977.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A268EA23; -.
DR OrthoDB; 9804431at2; -.
DR Proteomes; UP000216230; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:PAD69977.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:PAD69977.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000216230}.
FT DOMAIN 1..234
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 647 AA; 73328 MW; 261B1067646018D0 CRC64;
MNKTIGILAH VDAGKTTFSE QLLYHTKSIK TRGRVDHQNA YLDSHEIEKQ RGITVFADQG
MFQYEDCTYY LIDTPGHVDF SPEMERAIQV MDFAIVIVSA VEGIEGHTET VWNLLKKHNI
PTFFFINKTD RTGANVEMVL DEIRSQLTEN MIDLSEGFSD EKMTEELIEF IAERDEELLS
YYIENGYDSK LWLLKMKEMI KSSKIYPCSR GAALQDIGVK EFLEKFHLLT VTNYSTSEPF
GGRVYKIRYD EAGTRVTYIK ALCGTLKVRD DLVYGNGDIE KVTQIRKYNG KQFQQVNQAT
AGELIAVVGL SNAVVGDGVG VLKEASMYEM VPALKSKVVF EPGVNAKEAL RYFRILEAED
PSLNVTWVER LQEIQLHVMG TIQLEVLEQM VLERFSLKIH FEQPEILYKE TIENEVVGYG
HFEPLRHYAE VHLKLTPGER NSGIVFESTC HTDNLSVGLQ NLVGQHVLER EHHGLLTGSQ
VTDIKVTLLT GRDHNKHTHG GDFREATYRA LRQGLEKASN ILLEPFYKFK IKVDLDQMGR
VLSDIQAANG RFEAPETEGD KAIITGFAPV ATFMDYSTVL ASFTHGKGRI SLTFGGYHRC
HNEEEVIERI GYDKNADPEY TSSSIFCAKG QGFTVKWDEA EAMMHCL
//
