ID   A0A268KCI5_9BACI        Unreviewed;       451 AA.
AC   A0A268KCI5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Dihydropyrimidine dehydrogenase {ECO:0000313|EMBL:PAE44289.1};
GN   ORFNames=CHI06_02490 {ECO:0000313|EMBL:PAE44289.1};
OS   Bacillus sp. 7884-1.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=2021693 {ECO:0000313|EMBL:PAE44289.1, ECO:0000313|Proteomes:UP000216214};
RN   [1] {ECO:0000313|EMBL:PAE44289.1, ECO:0000313|Proteomes:UP000216214}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7884-1 {ECO:0000313|EMBL:PAE44289.1,
RC   ECO:0000313|Proteomes:UP000216214};
RA   Kalinowski J., Ahrens B., Al-Dilaimi A., Winkler A., Wibberg D.,
RA   Schleenbecker U., Ruckert C., Wolfel R., Grass G.;
RT   "Isolation and whole genome analysis of endospore-forming bacteria from
RT   heroin.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAE44289.1}.
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DR   EMBL; NPDD01000018; PAE44289.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A268KCI5; -.
DR   OrthoDB; 9803192at2; -.
DR   Proteomes; UP000216214; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000216214}.
FT   DOMAIN          12..119
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   DOMAIN          132..432
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   451 AA;  49124 MW;  C71D87783AAE962C CRC64;
     MQRISNTNLE LNFQEVERPL SHQEALEESN RCLYCYDAPC IKACPTGIDI PTFIKKITTG
     NLLGSAKTIM TSNPVGASCA RVCPTEELCE GACVLNHSTK PIMIGNLQRY ATDWAIKNEQ
     TLFQPGTANG KSVAVVGGGP AGLSVARELA RFGYEVTIFE AAEKAGGLNT YGIVSFRLPQ
     AISYWEVEQV EKLNVTIKTN TRVGKDISIK DLLEKFDCIV LAVGMAHVPD LGIEGEDLEG
     VYDAIEFVKK TKSGRLSNDF VGKQAVVIGA GNTAIDGATC SVRLGAEHVK ILYRRTKEEM
     TAYDFEYEFA KQDGVEFRWL TAPKRIIGDG NGKVTGIECL KMKLGEPDQD GRRRPHPVEG
     SEYVIPADVV IKAIGQTRHL ELIKGFGLEH DSGVVYVNKE TYQTSNPKIY ACGDVVFGKG
     KGDAMVVTAA QQGKLAAFSI HKQFTAVETA K
//