ID A0A268TQJ4_9HELI Unreviewed; 225 AA.
AC A0A268TQJ4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Urease subunit alpha {ECO:0000256|HAMAP-Rule:MF_01955};
DE EC=3.5.1.5 {ECO:0000256|HAMAP-Rule:MF_01955};
DE AltName: Full=Urea amidohydrolase subunit alpha {ECO:0000256|HAMAP-Rule:MF_01955};
GN Name=ureA {ECO:0000256|HAMAP-Rule:MF_01955};
GN ORFNames=BKH46_05760 {ECO:0000313|EMBL:PAF46942.1};
OS Helicobacter sp. 12S02634-8.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1476199 {ECO:0000313|EMBL:PAF46942.1, ECO:0000313|Proteomes:UP000216003};
RN [1] {ECO:0000313|EMBL:PAF46942.1, ECO:0000313|Proteomes:UP000216003}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=12S02634-8 {ECO:0000313|EMBL:PAF46942.1,
RC ECO:0000313|Proteomes:UP000216003};
RX PubMed=28827684; DOI=10.1038/s41598-017-09091-7;
RA Gilbert M.J., Duim B., Timmerman A.J., Zomer A.L., Wagenaar J.A.;
RT "Whole genome-based phylogeny of reptile-associated Helicobacter indicates
RT independent niche adaptation followed by diversification in a
RT poikilothermic host.";
RL Sci. Rep. 7:8387-8387(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000242, ECO:0000256|HAMAP-
CC Rule:MF_01955};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000256|ARBA:ARBA00004897,
CC ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SUBUNIT: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
CC {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC subunit family. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC subunit family. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- CAUTION: The orthologous protein is known as the gamma/beta subunit
CC (UreAB) in most other bacteria. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAF46942.1}.
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DR EMBL; MLAP01000007; PAF46942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A268TQJ4; -.
DR OrthoDB; 9797217at2; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000216003; Unassembled WGS sequence.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; Urease, beta subunit; 1.
DR Gene3D; 3.30.280.10; Urease, gamma-like subunit; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR HAMAP; MF_01955; Urease_beta_gamma; 1.
DR InterPro; IPR002019; Urease_beta-like.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR NCBIfam; TIGR00192; urease_beta; 1.
DR NCBIfam; TIGR00193; urease_gam; 1.
DR PANTHER; PTHR33569; UREASE; 1.
DR PANTHER; PTHR33569:SF1; UREASE; 1.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; Urease, beta-subunit; 1.
DR SUPFAM; SSF54111; Urease, gamma-subunit; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01955};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01955}.
FT REGION 1..102
FT /note="Urease gamma"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01955"
FT REGION 103..225
FT /note="Urease beta"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01955"
SQ SEQUENCE 225 AA; 24898 MW; 1FC6C9B7C167247F CRC64;
MKLNPKELDK LMLHYAGELA KKRKAKGIKL NYVEAIALIS SEIMELAREG KKSVADLMQE
GKKILKADDV MDGVAAMIHE VGVEVGFPDG TKLVTIHTPI EDNGKLTPGE LILKNEDIEI
NQGKQAIEIK VTNKGDRAIQ VGSHFHFFET NKLLEFDREK AYGRRLDIPS GTSVRFEPGE
TKTIALIEIG GSKRVFGFNN LADAQVNQDN KHIAMQNAKA KGFSK
//
