ID A0A268TUM7_9HELI Unreviewed; 616 AA.
AC A0A268TUM7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Mechanosensitive ion channel protein {ECO:0000313|EMBL:PAF47841.1};
GN ORFNames=BKH46_03140 {ECO:0000313|EMBL:PAF47841.1};
OS Helicobacter sp. 12S02634-8.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1476199 {ECO:0000313|EMBL:PAF47841.1, ECO:0000313|Proteomes:UP000216003};
RN [1] {ECO:0000313|EMBL:PAF47841.1, ECO:0000313|Proteomes:UP000216003}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=12S02634-8 {ECO:0000313|EMBL:PAF47841.1,
RC ECO:0000313|Proteomes:UP000216003};
RX PubMed=28827684; DOI=10.1038/s41598-017-09091-7;
RA Gilbert M.J., Duim B., Timmerman A.J., Zomer A.L., Wagenaar J.A.;
RT "Whole genome-based phylogeny of reptile-associated Helicobacter indicates
RT independent niche adaptation followed by diversification in a
RT poikilothermic host.";
RL Sci. Rep. 7:8387-8387(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAF47841.1}.
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DR EMBL; MLAP01000003; PAF47841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A268TUM7; -.
DR OrthoDB; 9775207at2; -.
DR Proteomes; UP000216003; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045042; YnaI-like.
DR PANTHER; PTHR43634:SF2; MECHANOSENSITIVE ION CHANNEL PROTEIN 2, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43634; OW CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 244..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 369..410
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 411..478
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 485..600
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 616 AA; 70400 MW; D1130B251DBC787B CRC64;
MKKFILSIIA VWICMLPLSL RAMENPDFVD LYVILKQIDQ INQVINTYKK DPQKSQEASL
YADQKDNLLK EFVSKINSHK EKIGIDITQN KAQQEEVQHK LDVSLQIKDP YSFSLNKITL
ESLQLDARMY DFLEKLRTKI DFFSQKDDVT KIVAPFLLEF AQKQMQKYTL PTQLGTSQKE
LLHHKLKEYQ IKLDTYVEIL SYIQKNASAV LPQSAAMNIG MEWVLEKIDY FIPLNTNNLG
IAKVVLSLVT LIILLGCRKI VAGVIMRLAD FFIKFTRHNK EIQNKIRHDI ITPISAFLLV
WSFDISLDIL YYPSLASPKV QVWFGVAYIA LIAWFVISLL KGYGTAFIMS IAQKSADGFR
KEVINLILKI LYFIVIVLAI LVILKHLGFN ISAIIASLGI GGLAVALAVK DMLANFFASV
MLLFDNSFSQ GDWIVCGDIE GTVVEMGLRR TTVRTFDNAL LFVPNSELAN KSIRNWNRRK
VGRRIKMSIG LTYDSSREQL QKCVQEIKEM LLNHPNISKD TDGRDSIDYQ VIFKKDIISM
DDYMGYKSTL FVFVDEFADS SINLLVYCFS KTVVWGEFLK VKEEVILEIM RIVAANNLSF
AFPSQSLYVE SLPKPL
//
