UniProt: A0A269PWL3

Database: UniProt
Entry: A0A269PWL3_9GAMM

LinkDB:  A0A269PWL3_9GAMM 
Original site:  A0A269PWL3_9GAMM

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (14)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
All databases (22)   

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ID   A0A269PWL3_9GAMM        Unreviewed;       380 AA.
AC   A0A269PWL3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Ribonuclease D {ECO:0000256|HAMAP-Rule:MF_01899};
DE            Short=RNase D {ECO:0000256|HAMAP-Rule:MF_01899};
DE            EC=3.1.13.5 {ECO:0000256|HAMAP-Rule:MF_01899};
GN   Name=rnd {ECO:0000256|HAMAP-Rule:MF_01899,
GN   ECO:0000313|EMBL:PAJ76334.1};
GN   ORFNames=CJF42_00080 {ECO:0000313|EMBL:PAJ76334.1};
OS   Pseudoalteromonas sp. NBT06-2.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=2025950 {ECO:0000313|EMBL:PAJ76334.1, ECO:0000313|Proteomes:UP000215836};
RN   [1] {ECO:0000313|EMBL:PAJ76334.1, ECO:0000313|Proteomes:UP000215836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBT06-2 {ECO:0000313|EMBL:PAJ76334.1,
RC   ECO:0000313|Proteomes:UP000215836};
RA   Wei Y.;
RT   "Pseudoalteromonas hadalis sp. nov., a facultative psychrophile isolated
RT   from New Britain Trench.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exonuclease involved in the 3' processing of various
CC       precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA
CC       molecule and releases 5'-mononucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_01899}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage that removes extra residues from the
CC         3'-terminus of tRNA to produce 5'-mononucleotides.; EC=3.1.13.5;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01899};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01899};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01899}.
CC   -!- SIMILARITY: Belongs to the RNase D family. {ECO:0000256|HAMAP-
CC       Rule:MF_01899}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAJ76334.1}.
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DR   EMBL; NQMR01000001; PAJ76334.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A269PWL3; -.
DR   OrthoDB; 9800549at2; -.
DR   Proteomes; UP000215836; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0033890; F:ribonuclease D activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042780; P:tRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR   CDD; cd06142; RNaseD_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   HAMAP; MF_01899; RNase_D; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR006292; RNase_D.
DR   InterPro; IPR048579; RNAseD_HRDC_C.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR01388; rnd; 1.
DR   PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR   PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF21293; RNAseD_HRDC_C; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 2.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01899};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW   Rule:MF_01899}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_01899};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_01899};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215836};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP-
KW   Rule:MF_01899}.
FT   DOMAIN          215..295
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   380 AA;  44212 MW;  B6E92568A3964A8E CRC64;
     MHSLCLENQY IKTQEQLDIY LLAIKESKIL AIDTEFMRRR TLYPELALIQ VYDGKNLALI
     DPCYELDLSK FWLILSDESI LKVLHSPSED LEVFMKHGQC VPKPLFDTQF AMGLLGFGNS
     VGFAMMVNKL LSLEIDKSES RTNWLQRPLT QRQLDYAAGD VLHLLPCFEI IKKQIDDKNW
     LDIILSESAL MAKKRQYQVP DEKLYLEIKN AWQLNSSDLA VLKELAVWRR DKARIKNLAL
     GFILKEHNMI EIAKSKPASI TALRKLPGIE VMTVNKSGKE ILKCIEKFTL LEKEHYPQKI
     VRLVDYPSYK TEVKLIKHRI DAVAKTQGIP TEVISSKKQI NQLLSWHWKC DKEQKKKKLT
     PDLLSCWRYK ILKGKLIEWE
//

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