ID   A0A269WAK3_9BACL        Unreviewed;       769 AA.
AC   A0A269WAK3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Metal-dependent phosphohydrolase {ECO:0000313|EMBL:PAK55312.1};
GN   ORFNames=CHH75_03380 {ECO:0000313|EMBL:PAK55312.1};
OS   Paenibacillus sp. 7541.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=2026236 {ECO:0000313|EMBL:PAK55312.1, ECO:0000313|Proteomes:UP000215741};
RN   [1] {ECO:0000313|EMBL:PAK55312.1, ECO:0000313|Proteomes:UP000215741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7541 {ECO:0000313|EMBL:PAK55312.1,
RC   ECO:0000313|Proteomes:UP000215741};
RA   Kalinowski J., Ahrens B., Al-Dilaimi A., Winkler A., Wibberg D.,
RA   Schleenbecker U., Ruckert C., Wolfel R., Grass G.;
RT   "Isolation and whole genome analysis of endospore-forming bacteria from
RT   heroin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAK55312.1}.
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DR   EMBL; NQLZ01000005; PAK55312.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A269WAK3; -.
DR   Proteomes; UP000215741; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:PAK55312.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215741};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          521..682
FT                   /note="HD/PDEase"
FT                   /evidence="ECO:0000259|SMART:SM00471"
FT   REGION          732..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   769 AA;  86395 MW;  5421B9554A031010 CRC64;
     MASKEPSTDK SIRAKNNGWK YSVATRYILF LLLALIFYIS LSSKLLPERY DIQVGTRSEK
     SITAPIQIED SKATLKAQEE AAERVQPIYT YVPLRNDVLV TQLLERIERL NQDTDISTQD
     KISIYREEIP RRVDDFVKNF VSANRGNDAY SSELLEEMLR VIEQQTYRIP EETFIKIPRL
     DSEDISQMKV VARDIVSSLM NETTDAQTPR AKVAEMVSTS SLDDRTAREV VQELARVSIT
     ANKFMDEEAT KEAKVEAREN TPPVFIKQGD ILVERGQLIT PELYELLGKN GLLKDEVNYW
     PELGLLIFSI LLSLGIFMFI RQSNAGYFKF NNSQLLMMVL IYVITLVSMH LAGYLQSDSR
     TYVGYLAPVA VGAILLTLLL EMSLAYFNVI IFTILASVIL NVQQGEIFDF RFGLFAAITS
     CVAIFSLHRA SQRSTLLKGG IMVSLFGTLT VFMMLLIKDG EWTGTETLYS LGFAFAGGLL
     TAILVIGLMP FFEVTFGILS ALKLVELSNP NHPLLRKLLT ETPGTYHHSV MVGNLSEAAA
     EAIGADGLLC RVGSFYHDIG KTKRPIYFIE NQNNMENPHD SIEPKLSKSI IVAHARDGVE
     MLKEYKLPKP IRDIAEQHHG TTFLHYFYHK ALRLAEEQGV EPDFTEDDFR YPGPKAQSKE
     AAIVGIADSV EAAVRSLRKP TVEQVESMIE KIIKGRLDDH QFNDCDLTMK ELDIIAKTLK
     ETVMGIFHSR IEYPEEVKRP NPKPAAAEAE AGPDGEAPSA SEEDKRRSV
//