ID A0A271IVB6_9BACT Unreviewed; 191 AA.
AC A0A271IVB6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=B1759_18010 {ECO:0000313|EMBL:PAP74499.1};
OS Rubrivirga sp. SAORIC476.
OC Bacteria; Rhodothermota; Rhodothermia; Rhodothermales; Rubricoccaceae;
OC Rubrivirga.
OX NCBI_TaxID=1961794 {ECO:0000313|EMBL:PAP74499.1, ECO:0000313|Proteomes:UP000216627};
RN [1] {ECO:0000313|EMBL:PAP74499.1, ECO:0000313|Proteomes:UP000216627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAORIC476 {ECO:0000313|EMBL:PAP74499.1,
RC ECO:0000313|Proteomes:UP000216627};
RA Kumagai Y., Kogure K., Yoshizawa S.;
RT "Whole genome sequence of Rhodothermus Rubrivirga sp. SAORIC476.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAP74499.1}.
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DR EMBL; MVOI01000015; PAP74499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A271IVB6; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000216627; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 10..189
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 191 AA; 20957 MW; 7100DC212EFC705A CRC64;
MTPPTRHTPE VVLIAAVAEA PGTEGDRLIG DGMDLPWHLP ADLKRFKALT LGYPLVMGRR
TFESLLHQFG GPLPNRENVV LTRHPTHVDH PGIHVYSGLP EAMDAFADRE RVFIGGGAGV
YASVLDPESP VQADRLELTL VEGTFSGDTF FPPYRHLLAE NGGPFRLAES VAHPAEAGRP
AFRFETFVRD R
//