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Database: UniProt
Entry: A0A271J707_9BACT
LinkDB: A0A271J707_9BACT
Original site: A0A271J707_9BACT 
ID   A0A271J707_9BACT        Unreviewed;       367 AA.
AC   A0A271J707;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR036497};
DE            Short=HDH {ECO:0000256|PIRNR:PIRNR036497};
DE            EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR036497};
GN   ORFNames=B1759_12735 {ECO:0000313|EMBL:PAP79213.1};
OS   Rubrivirga sp. SAORIC476.
OC   Bacteria; Rhodothermaeota; Rhodothermia; Rhodothermales;
OC   Rubricoccaceae; Rubrivirga.
OX   NCBI_TaxID=1961794 {ECO:0000313|EMBL:PAP79213.1, ECO:0000313|Proteomes:UP000216627};
RN   [1] {ECO:0000313|EMBL:PAP79213.1, ECO:0000313|Proteomes:UP000216627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAORIC476 {ECO:0000313|EMBL:PAP79213.1,
RC   ECO:0000313|Proteomes:UP000216627};
RA   Kumagai Y., Kogure K., Yoshizawa S.;
RT   "Whole genome sequence of Rhodothermus Rubrivirga sp. SAORIC476.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036497};
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036497}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PAP79213.1}.
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DR   EMBL; MVOI01000006; PAP79213.1; -; Genomic_DNA.
DR   Proteomes; UP000216627; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|PIRNR:PIRNR036497};
KW   Complete proteome {ECO:0000313|Proteomes:UP000216627};
KW   Isoleucine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Kinase {ECO:0000313|EMBL:PAP79213.1};
KW   Methionine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   NADP {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|PIRSR:PIRSR036497-2};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036497};
KW   Reference proteome {ECO:0000313|Proteomes:UP000216627};
KW   Threonine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Transferase {ECO:0000313|EMBL:PAP79213.1}.
FT   DOMAIN       27    152       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      160    359       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      27     32       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    228    228       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     101    101       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     125    125       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     213    213       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   367 AA;  37684 MW;  6239DC15BF8F58D8 CRC64;
     MTASPAFHPA APVAGSPARP LDVYLAGVGT VGRALLGQIA DLAPGTLRLV GACTRSRSGL
     DLGGLDPAAP ALDPAPPDWP AILNRLAARA AGAPVVFVDA TGSPEVADLV EPMLAAGVSV
     VTPSKLANTR SQAAYDRLRQ LSATGAVHYR YETTAGAGLP LVRLIEDLVA TGDRVQSIRG
     VLSGTMTFLF GQIERGASFS TAARRAFEQG YSEPDVRDDL SGEDVARKLL ILARSAGLRV
     ERSDVEVESL VPSEAVGVPV TLVPDALAAA DADWSRRVAE AEAEGRRLRY VGEVRVEGGR
     PQLRVGTVAV PAGSPLGTLS GADNLVEITT ERYAASPIVV RGPGAGAQVT AAGVLADVLA
     VARAVAE
//
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