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Database: UniProt
Entry: A0A284QTC2_9AGAR
LinkDB: A0A284QTC2_9AGAR
Original site: A0A284QTC2_9AGAR 
ID   A0A284QTC2_9AGAR        Unreviewed;       838 AA.
AC   A0A284QTC2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   03-JUL-2019, entry version 12.
DE   RecName: Full=Urease {ECO:0000256|PIRNR:PIRNR001222};
DE            EC=3.5.1.5 {ECO:0000256|PIRNR:PIRNR001222};
DE   AltName: Full=Urea amidohydrolase {ECO:0000256|PIRNR:PIRNR001222};
GN   ORFNames=ARMOST_03018 {ECO:0000313|EMBL:SJK99707.1};
OS   Armillaria ostoyae.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Physalacriaceae;
OC   Armillaria.
OX   NCBI_TaxID=47428 {ECO:0000313|EMBL:SJK99707.1, ECO:0000313|Proteomes:UP000219338};
RN   [1] {ECO:0000313|EMBL:SJK99707.1, ECO:0000313|Proteomes:UP000219338}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C18/9 {ECO:0000313|EMBL:SJK99707.1,
RC   ECO:0000313|Proteomes:UP000219338};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000256|PIRNR:PIRNR001222};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001222,
CC         ECO:0000256|PIRSR:PIRSR001222-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRNR:PIRNR001222, ECO:0000256|PIRSR:PIRSR001222-51};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR001222}.
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR001222-50}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the metallo-
CC       dependent hydrolases superfamily. Urease alpha subunit family.
CC       {ECO:0000256|PIRNR:PIRNR001222}.
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DR   EMBL; FUEG01000002; SJK99707.1; -; Genomic_DNA.
DR   OrthoDB; 183108at2759; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000219338; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   HAMAP; MF_01954; Urease_beta; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR008221; Urease.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001222; Urease; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000219338};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001222, ECO:0000256|PROSITE-
KW   ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001222,
KW   ECO:0000256|PIRSR:PIRSR001222-51};
KW   Nickel {ECO:0000256|PIRNR:PIRNR001222, ECO:0000256|PIRSR:PIRSR001222-
KW   51}; Reference proteome {ECO:0000313|Proteomes:UP000219338}.
FT   DOMAIN      398    838       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    589    589       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       403    403       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       405    405       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       486    486       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       486    486       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       515    515       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       541    541       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       629    629       Nickel 1. {ECO:0000256|PIRSR:PIRSR001222-
FT                                51}.
FT   BINDING     488    488       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     486    486       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR001222-50}.
SQ   SEQUENCE   838 AA;  89657 MW;  908C9CE32C6D3236 CRC64;
     MHLLPREEAK LLLHQAGFLA QKRLARGLRL NQGEAIALIA SQLQERIRDG KHSVAELMQH
     GKDMLGRRHV LPSVAGLLHE IQVEGAFVDG VFLVTVHDPI CTESGNLENA LYGSFLPIPA
     NNAFPVADVS EYSREKAPGA IIARKEPIII NKGRERISLR VTNNGDRPIQ IGSHYHFIET
     NPALSFDRGK AYGKRLDIPA GTAVRFEPGD VKTVTLCAIA GGQIISGGNR LASGVVDLDR
     SDQIVSALVQ KGFAHIPEPG ALEVKTDTDI SREAYISMFG PTTGDRVRLG DTALWIEVEH
     DKTVYGDEVK FGGGKSIREG MGQATDRSSK ETLDLVITNA LIIDWSGIYK ADIGVKDGRI
     CGIGKAGNPD VMANVHPSLI IGSSTEVIAG EKLIITAGAV DAHVHYICPQ QVEEALAAGT
     TTMIGGGTGP SAGTNATTCT PSPFYIRHML RATDGLAMNF AFTGKGNDAG PTALEEVVHA
     GAAGLKLHED WGSTPATITN CLDVGDKYDV QVNIHTDTLN ESGFVESTIA AFGNRTIHTY
     HSEGAGGGHA PDIIVVCGQK NVLPSSTNPT RPYTNNTLDE HLDMLMVCHH LDRSIPEDLA
     FAESRIRAET VAAEDVLHDI GAIAMISSDS QAMGRVGEVV SRTWRTASKM REFRGPLASS
     GDSEGVDNAR VKRYIAKYTV NPAITHGISH AVGHVAVGTL ADLVLWKPEN FGAKPEMVLK
     SGVIAWSQMG DANASIPSVQ PFYSKPMWGA KPGSAALNSV AFVSEVSISS GAIASYDLNK
     DAVAVKGCRN ITKKDMKWND LIPKMSVDPE TYEVRADGEL ADVAPAEKLP LARAYNFF
//
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