ID A0A285E8S3_9ACTN Unreviewed; 544 AA.
AC A0A285E8S3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:SNX95472.1};
GN ORFNames=SAMN06893097_102168 {ECO:0000313|EMBL:SNX95472.1};
OS Geodermatophilus sabuli.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Geodermatophilus.
OX NCBI_TaxID=1564158 {ECO:0000313|EMBL:SNX95472.1, ECO:0000313|Proteomes:UP000219514};
RN [1] {ECO:0000313|EMBL:SNX95472.1, ECO:0000313|Proteomes:UP000219514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46844 {ECO:0000313|EMBL:SNX95472.1,
RC ECO:0000313|Proteomes:UP000219514};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR EMBL; OBDO01000002; SNX95472.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285E8S3; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000219514; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003968};
KW Reference proteome {ECO:0000313|Proteomes:UP000219514}.
FT DOMAIN 85..108
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 253..267
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT REGION 133..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 16..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 87
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 544 AA; 57641 MW; CFB3CFC758D04FBE CRC64;
MPPPPEWDVV VVGAGTSGAP LAARLADAGR RVLVLEAGAD HARPEDFPPV LRDAAAMGAA
VPGHPANWDL SGILTEEVTF PVPRGRVVGG SSALNGGYFI RGTRADFDGW AAAGNDLWSA
DRVLPSFVRL ESDREYGDRP GHGSAGPVPV RRPQEGHPLA DAFAAATGDL GFPAEPDKNA
DGAPGYGPVP LNVADGVRAN TAMAYLSPRR GHRGLTVRGG VHARRVVVEA GRAVGVQTDD
GVVRAAEVVL SAGAVGSPQL LLLSGIGPAD DLRALGIDVV ADVPGVGSEF TDHPDLYVTY
RPARRLPMPR DLHPLHGVLH TTSDGGGTPG DLEVMPWLKP FSRVMLDRSA GSRLAGVTDV
LRRPADTVRA LRGASLHRLV DTARRRDDLF LGVALQAEDS RGRLSLTSAD PRVQPRIEYR
YLTEASDRRR MREVVRLAAE LLRAPSLAPL VAERTGLPDD VLTDDRQLDR WVRRHLATAV
HLAGTARMGP AGDPGAVVDQ HLRVRGVEGL RVVDTSVMPW VTTRGPAATA VMIGERAAEL
MTGA
//
