ID   A0A285EEM6_9ACTN        Unreviewed;       385 AA.
AC   A0A285EEM6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Acetyl-CoA acyltransferase {ECO:0000313|EMBL:SNX97495.1};
GN   ORFNames=SAMN06893097_107137 {ECO:0000313|EMBL:SNX97495.1};
OS   Geodermatophilus sabuli.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=1564158 {ECO:0000313|EMBL:SNX97495.1, ECO:0000313|Proteomes:UP000219514};
RN   [1] {ECO:0000313|EMBL:SNX97495.1, ECO:0000313|Proteomes:UP000219514}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 46844 {ECO:0000313|EMBL:SNX97495.1,
RC   ECO:0000313|Proteomes:UP000219514};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; OBDO01000007; SNX97495.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A285EEM6; -.
DR   OrthoDB; 3761315at2; -.
DR   Proteomes; UP000219514; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR   PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:SNX97495.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219514};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SNX97495.1}.
FT   DOMAIN          5..252
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          261..381
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        89
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        339
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        369
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   385 AA;  39564 MW;  69B4C79C8C49C826 CRC64;
     MRDAVICAAV RTPVGKRGGG LSGVHAVDLS AHVLEALVER SGIDPAVVDD VIWGCVSQIG
     EQTYNVARNA ALAAGWPETV PGTTIDRQCG SSQQAVAFAA ASVISGQADV VVAGGVESMS
     RVPMGSSIGD GSAGRPLGPR FMERYGVAPN QGVGAEMIAE RWGFSRTQLD EFSLASHEKA
     AKAQADGAFD EEIAPVTTPE GTVVRADEGV RPGGTLEKLA SLKTPFKADG VISAGNASQI
     SDGSAALLVT TSEKARELGL RPLVRIHTTV MAGDDPVIML TAPIPATHKV LQRSGLSVDE
     IGIFEVNEAF APVPLAWQVE TGAALDRVNP RGGAIALGHP LGGSGARIMT TLVHSMLATG
     TRYGLQTMCE GGGMANATIL ELIAA
//