ID A0A285HNX3_9RHOB Unreviewed; 697 AA.
AC A0A285HNX3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SNY36391.1};
GN ORFNames=SAMN06297129_0162 {ECO:0000313|EMBL:SNY36391.1};
OS Pseudooceanicola antarcticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pseudooceanicola.
OX NCBI_TaxID=1247613 {ECO:0000313|EMBL:SNY36391.1, ECO:0000313|Proteomes:UP000231655};
RN [1] {ECO:0000313|EMBL:SNY36391.1, ECO:0000313|Proteomes:UP000231655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12662 {ECO:0000313|EMBL:SNY36391.1,
RC ECO:0000313|Proteomes:UP000231655};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
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DR EMBL; OBEA01000001; SNY36391.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285HNX3; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000231655; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 296..471
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 476..570
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 604..688
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 697 AA; 73596 MW; DCAA09388B448173 CRC64;
MPDGVVGEVV TTEVVGDVAL VCIDNPPVNA SGHAVRVGLV GAIEALNAEA GVKAIAIWCA
GRTFMAGADI REFGKPSKEP VLPEVYNILE ASEIPVVAVM HGTALGGGFE LGLAAHARVA
IAGSKVGLPE VLIGLLPGAG GTQRLPRLAG VDFALDMSLS GRQVSVEEAQ AAGAIDRVVE
GNPRDVALSM AQEVVAGTLP TRRTSEISIE IDHTALDGIR AATQKKSPHL VNPLKCIDAI
AAADQPIAEG LKVERQCFLD CMETPQRAGL IHAFFGERAV SNIPEAKGET RDIQSVGVIG
GGTMGSGIAT ACLLAGLPVT LVEVAQEGLD RGVATITKNL EGAVSRGKMS EAKKEAALAS
LSPALELDAL ADVDLVIEAV FEDMGVKREI FGKLDAICKP DAVLASNTSY LDVNEIAEST
SRPGDVLGLH FFSPAHVMRL LEIVQGKQTA PDVLATGFAL AKRLRKVGVL AQVCDGFIGN
RILAHYALCS GYLVLDGASP AQVDAALEGF GFAMGPHKVG DLAGLDIGWM TRKRKAATRD
PAERYAGQIP DRICENGWFG RKTGKGYYLY EGGAPVPNPE VATIIDEVRA EQGITPKSFT
DDEIVERYMT AMISEAARVV EDGTAKRPLD VDMVFLFGYG FPRFRGGPLH YADTLGAAEL
VARIERYAEE DPHYWQVPDI LHRMAADGTS FADLNKG
//
