ID   A0A285L0X0_9NOCA        Unreviewed;       387 AA.
AC   A0A285L0X0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Long-chain alpha-pyrone synthase {ECO:0000313|EMBL:SNY78554.1};
GN   ORFNames=SAMN04244553_1324 {ECO:0000313|EMBL:SNY78554.1};
OS   Nocardia amikacinitolerans.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=756689 {ECO:0000313|EMBL:SNY78554.1, ECO:0000313|Proteomes:UP000219565};
RN   [1] {ECO:0000313|EMBL:SNY78554.1, ECO:0000313|Proteomes:UP000219565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45537 {ECO:0000313|EMBL:SNY78554.1,
RC   ECO:0000313|Proteomes:UP000219565};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; OBEG01000001; SNY78554.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A285L0X0; -.
DR   STRING; 1379680.GCA_001612615_02232; -.
DR   OrthoDB; 9786288at2; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000219565; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219565}.
FT   DOMAIN          31..229
FT                   /note="Chalcone/stilbene synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00195"
FT   DOMAIN          251..383
FT                   /note="Chalcone/stilbene synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02797"
FT   ACT_SITE        169
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ   SEQUENCE   387 AA;  40788 MW;  C77E4AE2DA8918C5 CRC64;
     MSIVLDQLTR TAAHTRRHMT LSAPPPTVPV VEAIATGAPS LVLDQSVAAD WMAGQFTDLD
     QQTRVRRIFG KTMIDTRRFA VDPLDPELHA PGADAVTIQD RMRLFYHHAV PLATDVARRA
     LAGVDPSDLG LLVFATSTGV IAPGVDVAVV ENLGLPRSIA RLVVNFMGCA AAMNGIRTAS
     DFVRANPGKK AMVVCIELNS VHAVPVEDVG DAVAHSLFGD GCGAVVIGAR RGAERAEAGT
     IVVRDQFTHL FEGTEDGIAV GVNHDGISCE LSENVPRYIY DGVAPVVGDV LRRNGLRQSD
     IDVWAIHPGG PKILLESARS LGLAPEAAST SWEVLAEYGN MSSVSLIFVL ERIAGAAVAG
     KSISAGVAFS FAPGVTIEGF LFDVVGR
//