ID   A0A285L7I3_9NOCA        Unreviewed;       392 AA.
AC   A0A285L7I3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Cystathionine gamma-lyase {ECO:0000313|EMBL:SNY80878.1};
GN   ORFNames=SAMN04244553_2452 {ECO:0000313|EMBL:SNY80878.1};
OS   Nocardia amikacinitolerans.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=756689 {ECO:0000313|EMBL:SNY80878.1, ECO:0000313|Proteomes:UP000219565};
RN   [1] {ECO:0000313|EMBL:SNY80878.1, ECO:0000313|Proteomes:UP000219565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45537 {ECO:0000313|EMBL:SNY80878.1,
RC   ECO:0000313|Proteomes:UP000219565};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; OBEG01000002; SNY80878.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A285L7I3; -.
DR   STRING; 1379680.GCA_001612615_02786; -.
DR   Proteomes; UP000219565; Unassembled WGS sequence.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Lyase {ECO:0000313|EMBL:SNY80878.1};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219565}.
FT   MOD_RES         211
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   392 AA;  41818 MW;  93BD37F2DCA4D009 CRC64;
     MVRERLIYAV PMSELGFSTR AVHAGFDPDP QTGAVNVPIY ASSTFAQDGV GGLRGGYEYA
     RTGNPTRTAL EENLAALESG RYGRAFASGM AATDCALRAT LRPGDHIVIP DDAYGGTFRL
     IDKVFSQWGI EHSPAHVFNT DEMRAAIRPN TKLIWVETPT NPLLSIGDIP ALADIAHAAG
     AKLVVDNTFA TPYLQQPLLL GADIVVHSTT KYLGGHSDVV GGALITNDKE LDAAFAFLQN
     GAGAVPGPFD AFLTMRGTKT LALRMERHCD NAETIADFLT KHPAISQVIY PGLPDHPGHV
     VADKQMRRFG GMISVRLHGG KEAAHDFCSR TKIFTLAESL GGVESLIEHP GAMTHASTEG
     SLLEVPADLV RLSVGIEDIS DLLADVEQAL GK
//