ID A0A285LX83_9NOCA Unreviewed; 2872 AA.
AC A0A285LX83;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SNY88256.1};
DE Flags: Fragment;
GN ORFNames=SAMN04244553_5224 {ECO:0000313|EMBL:SNY88256.1};
OS Nocardia amikacinitolerans.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=756689 {ECO:0000313|EMBL:SNY88256.1, ECO:0000313|Proteomes:UP000219565};
RN [1] {ECO:0000313|EMBL:SNY88256.1, ECO:0000313|Proteomes:UP000219565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45537 {ECO:0000313|EMBL:SNY88256.1,
RC ECO:0000313|Proteomes:UP000219565};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; OBEG01000006; SNY88256.1; -; Genomic_DNA.
DR OrthoDB; 4516163at2; -.
DR Proteomes; UP000219565; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000219565};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNY88256.1}.
FT DOMAIN 1014..1089
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1106..1523
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2718..2793
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:SNY88256.1"
SQ SEQUENCE 2872 AA; 299511 MW; 4F867EFB35B81EED CRC64;
SLEDACVLVA ARGRLMQALP AGGAMVAVGA SEGDVLPLLT GIDGVSIAAV NGPSSVVLSG
VEDAVQTVVD ACVEHGWRTH RLRVSHAFHS ALMEPMLAEF ASVVEGLVFD RPSIALVSTV
TGARITEEMT DPGYWVGQVR DTVRFADAVA AMAEMGVSRF AEVGPDAVLT PMIAQIADSG
QLTATPAIVP LARRSRADES AVLGGVAALF VAGADVDWAG LHPGGRRIDL PTYAFQHERF
WLDPRHMLAK SWLGAELGGV GSAGLDAVEH PLLAAMVSHP ESGEVSFTGR WSVDSMRWLA
DHSVLGVVLL PGTGFVELAS YVGGVLGCEV VDELVLHTPL TMPAEGSVAV QVVVAGADES
GRRRLTVHSR QTAEVPWSLH AEGVLAPGET AADFDLAAWP PAGAQPTPLT GVYDELFDLG
YGYGPFFQGL QAAWRRGDEL FAEVTLPDPQ DGNGFGVHPA LLDAALHVGI VHGLRDGVGD
FPALPFTWNR VVLHAAGAAA VRVRIVVDGT RFTVQLADDH GRPVLSVGAL VSRPVSADRL
GADRAAESLF RVDWSTVAPP AALAEPGRLA ALGWGRSSGE VRGYGDLAAL IADLDANPDA
VVPEIVLLEC PVEDGAPPQA ARKVANRVLD TVQGWLAETR FAGSRLVVTT RNAVAVDDSD
SVRLDQAPVW GLVRAAQAEN PGRFQLLDLD GDHDPVSVAT AAMAAEPEAA LREQEVLVPR
FGRHASDAVA RPLPPGTVLV TGGTGGLGAV IARHLVTEHG VRQLILTSRR GLDAPGATEL
RDELVELGAQ VAVAACDVSD RAAVATLLDG ISAEHPLVGV VHAAGIADNG LIESMTPDRL
GNVLGPKADA AWHLHELTRD TALSLFVLLS SAGGLVLAAG QANYAAANVF LDALATHRRE
LGLPATAIDY GLWARSTGLG AELSEDDFDR MRRLGFPPLT EAEGLALFDA AIAAEAAQVV
ALRVDAAVLR TRGEQIPALL RAIAPAPVRR ATRTAAGQAF AQRLAGLSDT DRAAALLELV
RGTAAETLGH ASGAAVEPQQ AFQQLGFDSL SAIEFRNKLN TATGLQLPAT LIFDYPNPQV
VAEFIDAQFT GTSQDIEITT GTAIGDDRIA VVAMGCRYPG GIASPEDLWR LVASGGEAIG
ELPDDRGWDI DGIYDPEPGK AGKTYTRHGG FLYSAADFDA DFFGISPNEA TVMDPQQRVL
LEVSWEALER AGLDPSVLRG SSTGVFTGVM YHDYAQGAGT GNNAGGSLVS GRIAYTLGLE
GPAVSVDTAC SSSLVALHLA AQSLRSGECD LALAGGVAVM SAPDMFLEFS RQRGLSPDGR
CKSFADAADG VGWSEGAGVL VLERLSDARR NGHRVLAVIA GSAVNQDGAS NGFAAPNGPS
QRRVIRQALA NAGVSPVDVD AVEAHGTGTT LGDPIEAQAL MATYGRDRDA ARPLWLGSLK
SNIGHAQAAA GVGGVIKMVM AMRHGLLPQT LHVDQPSTKV DWSEGQVRLL TEPVAWPEAD
RPRRAAVSSF GLSGTNAHLI IEQAPVVDLA PEVETAPVGG VLPWVLSARS GAALADQAAR
LAAQVGDHED DPIDVGFSLV DSRMLFDHRA VVFATDRDAL LAGTHALSRD ESLPGVVSGR
VVTGSTGVVF SGQGAQWAGM AAELRAVYPV FAEHFDAIVA QLDPMLDQQI ALNTALSDED
SVDRTVFAQA GLFAFEVALF RLLESWGVRA DVVAGHSIGE VAAAHVAGVL SLEDACVLVA
ARGRLMQALP AGGAMVAVGA SEVDLLPLLS GEVSIAAVNG PSSVVLSGIE DDVLAVVAKC
TEQGWRTHRL RVSHAFHSAL MEPMLAEFAS VIEGLTFGRP TIPLVSTVTG ARITDEMTDP
AYWVGQVRDT VRFADAVAAM ADMGVSRFAE VGPDAVLFPM VNQIIDGATA TTAPTVVALA
RRGQADASAV MAGTAGLFVT GAHVDWARLY AGTGARRIDL PTYAFQRQRY WMAAGTATGG
DARSMGFAAS EHPLVSAVVS QPESDAIALS GRLSVRTQPW LADHAVMDTV LFPGTGLVEL
AMHAGEQLGC AVLDELVLRA PLVLSDAAGV AVRVVVDAED VAGRRRVRIF SRLDDTVETP
WTLNAEGALA PEDDSAAVDL VSWPPADAVA VDIDGVYDAL DAQGYHYGPV FQALRAVWRG
ADGVYAEVEL PEAARGEAGR FGVHPALLDA ALHALRFADE TGSEESGLVL PFEWSGVTVH
AAGADALRVR LTRIGERGVA LDLADSTGVA VATVRHLASR PVDAAQLTAG TSIARTAVFD
VDWTPITVSE NEVASVAWAD LGDVGEPVPP AVVLDCPAGN DPDTVRAATH GVLQVLQSWF
AEPRFGESVL VVRTGGAVSV SGEGVSNLAG AAVGGLVRAA QTEHPGRIVL IDSDSELGGL
LGGILAAGEP QVAVRAGRVH AARLARVVAT DTPATGSFDP DDTVLITGAS GYLGGLFARH
LVATRGVRRL LLLSRRGESA TGAIELREEL RQLGAEVEFV ACDVADRGAL ARVLVGIPAD
HPLTGVFHMA GVLDDGAIAS LTPARMDAVF GPKVDAALHL HELTAELPLR AFVLFSSAAG
AFGNAGQGNY AAANACLDAL AAHRRASGLP GTSLAWGLWS MDGGMAAELG DTERRRMSRS
GMLPLSQEQG LALFDAATAL ETPAPILARL DLEAMRGAGS EVPALFSGLV PQRRKAGANA
SAALRARLAS TPDGERLGVL VEIVRGQVAA ILGHRNAHVI APDRPFSELG FDSISAVEFR
NALATATGLR LPATAVFDYP SPQALAEYLA GQFDGHRDAE QVTELSENSI RNALQTIPLA
RLREAGLLDA LMKLANGQDS QDDTDQTVTD ESIDELDIDG LIDLAYNNSS ED
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