ID A0A285N3Q4_9AQUI Unreviewed; 800 AA.
AC A0A285N3Q4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SAMN06265182_0543 {ECO:0000313|EMBL:SNZ04060.1};
OS Persephonella hydrogeniphila.
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Persephonella.
OX NCBI_TaxID=198703 {ECO:0000313|EMBL:SNZ04060.1, ECO:0000313|Proteomes:UP000219036};
RN [1] {ECO:0000313|EMBL:SNZ04060.1, ECO:0000313|Proteomes:UP000219036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15103 {ECO:0000313|EMBL:SNZ04060.1,
RC ECO:0000313|Proteomes:UP000219036};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; OBEI01000001; SNZ04060.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285N3Q4; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000219036; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 4.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 7..461
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 433..467
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 800 AA; 90529 MW; F980F3DD40BB5E57 CRC64;
MSEIIRQPIE EEVKSAYLDY AMSVIVGRAI PDVRDGLKPV QRRILYAMYE EGMYPNKPYK
KSARTVGNVI AKYHPHGDAA VYDALVRMAQ DFTLRYPLIQ GQGNFGSIDG DPPAAMRYTE
ARLTKLAMEM LADIDKNTVD MKENFDASLM EPEVLPAKFP NLICNGAAGI AVGLSTNIPP
HNFTEIAEAL KYLAEFPNAT VEELCQFVKG PDFPTGGVLI TPKEEIVKIY KDGRGSVTVK
GKARIERLPG NRHRIIIYEI PYQVNKVEFI KRIAELVRKG QEKGISDLRD ESDRDGIRII
VELKREADPE KVLKKLYRRT QLQKSIPINF TVLVGKQPKT LDLKGILWEF IKHRIEVITR
RTLYELDKAE SRLHIVEGLL KALENADRVI EIVRGSKDVS SAKELLKEEF GLSDAQSQAI
LDMRLSRFTA LEGDKLYQEA DELRLKIEEY QKILSSEEEK IRVFIEEMDY LLEKFGDERK
TMVIEEKGEQ LTFEEDYILA VLSSGRIINR KFDEKEEKEE VYQKVLNEVS TTVKPGEKLI
SIQEIKSSTP IAFVTDRGKA YWSLVADLPK GEGKLNIEEG EIVGTAFKGE GEEDRLFILT
KNGIIKRMSY EDIFYKSQNH TIIPLSEDDE VVVAFADDHP SVLAVYTRKG DLLMFDRSQV
RVTGDKAKGV EAIDLDEGDE VRGGFLINSE EYVLTITEKG YTKLVKKEEF YTKEGKLKKR
GQKGLMAVKL SKDDALSAAT GVHMGDTLLL STEKGRVLKL KVDEMKIPVA KRTAMGEQLI
KIEGDKVVKI VKPKISESQD
//
