ID A0A285NSD0_9AQUI Unreviewed; 200 AA.
AC A0A285NSD0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DNA gyrase/topoisomerase IV, subunit A {ECO:0000313|EMBL:SNZ11877.1};
GN ORFNames=SAMN06265353_0351 {ECO:0000313|EMBL:SNZ11877.1};
OS Hydrogenobacter hydrogenophilus.
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae;
OC Hydrogenobacter.
OX NCBI_TaxID=35835 {ECO:0000313|EMBL:SNZ11877.1, ECO:0000313|Proteomes:UP000218627};
RN [1] {ECO:0000313|EMBL:SNZ11877.1, ECO:0000313|Proteomes:UP000218627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2913 {ECO:0000313|EMBL:SNZ11877.1,
RC ECO:0000313|Proteomes:UP000218627};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; OBEN01000001; SNZ11877.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285NSD0; -.
DR Proteomes; UP000218627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SNZ11877.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..198
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 200 AA; 22148 MW; 7FD0C7A011C7766D CRC64;
MGILIIIFLE ITTVPIEEEV KQSYIDYAMS VIVGRAIPDA RDGLKPVQRR ILYAMYQMNL
TPDKPFVKSA RIVGTVLGYY HPHGDQAVYD ALVRMAQDFN MRYPLIKGQG NFGSIDGDPP
AAMRYSEAKL SKVAIKLLED IEEDTVDFVP NFDGSTLEPS VLPSKFPNML CNGSTGIVVG
LATVIASALL VVFYYRHLAI
//
