ID   A0A285NZ41_9PSED        Unreviewed;       735 AA.
AC   A0A285NZ41;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Dimethylhistidine N-methyltransferase {ECO:0000313|EMBL:SNZ14752.1};
GN   ORFNames=SAMN05660463_02849 {ECO:0000313|EMBL:SNZ14752.1};
OS   Pseudomonas sp. URIL14HWK12:I9.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1261633 {ECO:0000313|EMBL:SNZ14752.1, ECO:0000313|Proteomes:UP000232228};
RN   [1] {ECO:0000313|EMBL:SNZ14752.1, ECO:0000313|Proteomes:UP000232228}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=URIL14HWK12:I9 {ECO:0000313|EMBL:SNZ14752.1,
RC   ECO:0000313|Proteomes:UP000232228};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00037882}.
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DR   EMBL; OBEM01000006; SNZ14752.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A285NZ41; -.
DR   OrthoDB; 9768004at2; -.
DR   Proteomes; UP000232228; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0052699; P:ergothioneine biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR024775; DinB-like.
DR   InterPro; IPR017806; EgtB.
DR   InterPro; IPR035094; EgtD.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   NCBIfam; TIGR03440; egtB_TIGR03440; 1.
DR   NCBIfam; TIGR03438; egtD_ergothio; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF12867; DinB_2; 1.
DR   Pfam; PF03781; FGE-sulfatase; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SNZ14752.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000232228};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNZ14752.1}.
FT   DOMAIN          29..141
FT                   /note="DinB-like"
FT                   /evidence="ECO:0000259|Pfam:PF12867"
FT   DOMAIN          197..337
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
FT   DOMAIN          435..734
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  81755 MW;  044AEAFACAC31FBA CRC64;
     MTSPLPQAHP LQPASSKPRL HTSLRQRYGA VRAHSLALAA PLSAEDMGAQ SMPDASPTKW
     HLGHTTWFFE TFLLIPHLPG YQRFDETFGY LFNSYYEAVG PRQPRPQRGL MTRPALSQVQ
     AYRAHVDTHM QALLAQGLAD AECALVELGL NHEQQHQELI LMDILHLFSC SALKPAYNPD
     WPRDDRGRAG RMRHHGAGLV EIGHDGEHFA FDNEGPRHKV YLAPFEISDR LVTNGQWLAF
     IGDGGYRQPA HWLSEGWATV QADGWQAPGY WQRVPEYPEH LAQGWQAMTL RGLEPLDPDA
     PVTHLSYFEA SAYASWAEAR LPSEAEWELA RRTGTLEQAD DVAWQWTQTA YSAYPGFKPA
     KGAVGEYNGK FMCNQFVLRG GCQFTPAGHT RPTYRNFFPA NARWARAGLR LARDSRANAL
     HPVPSPAATD PQEGFRHDVL AGLKASPKAL SPKYFYDAKG SRLFEEICTL PEYYPTRAEA
     GLLRRIVPEL SALIPNGASL VEFGSGASEK TRLLLDAAPQ LGAYVPIDIS ADALGRACET
     LRCTYPHLNI TPLTGDFTQP LSLPADARGR ARVGFFPGST LGNFDEEEAV AFLRAARHSL
     GRDACFIVGV DMVKPVELLE AAYDDRQGVT AAFNKNLLTR INRELGADFD LDAFDHNARW
     NPGQQRIEMH LVARSPQRVT IAGEVFTFAK GETLHTENSH KFTVDKLSML AARAGWKLTE
     QWLSEAPEVG MFCLR
//