ID   A0A285QKB0_9ACTN        Unreviewed;       544 AA.
AC   A0A285QKB0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Type VII secretion-associated serine protease mycosin {ECO:0000313|EMBL:SOB82395.1};
GN   ORFNames=SAMN06272789_2558 {ECO:0000313|EMBL:SOB82395.1};
OS   Streptomyces sp. 1331.2.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1938835 {ECO:0000313|EMBL:SOB82395.1, ECO:0000313|Proteomes:UP000219030};
RN   [1] {ECO:0000313|Proteomes:UP000219030}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1331.2 {ECO:0000313|Proteomes:UP000219030};
RA   Varghese N., Submissions S.;
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240}.
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DR   EMBL; OBMJ01000001; SOB82395.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A285QKB0; -.
DR   Proteomes; UP000219030; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR   PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000219030};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        484..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          143..405
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          389..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          510..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..458
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..544
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        152
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        186
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        356
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   544 AA;  56263 MW;  54D2B941B1A97492 CRC64;
     MSRWVRRPWS PRQGRVVRRR SWRASLPGWC WWPAWCSCWC GGGSRPCSLR PLFRWCRRIS
     RCRRRTSRRC RRRTIRTRGS RGASVVGDRV GNRWTRRFVA VGVASLWVAG ALAGPAAADE
     TVRARQWHLD AMHAPEMWKT STGQGVTVAV IDGGFRLDHP DLVGQFLPGK DFSGSPGGVG
     TFGDGHGTEM SSLIAGTGKG VGGTGAYGLA PGAKILPLKI NNGSVGALVS ADFLDQIGQA
     VNYAVDQGAK VINISQGIAA VTAMPSDVDK LDRILAAARS KGVLVVSSVG NKAQSGNLLS
     YPGGLPNVVG VGAIDRQGTV TAESETGPHV ALVAPGDEIL AGCTSETEYC KSHGTSDAAA
     LVSASAALVW AVHKDWTANQ VLRVLINTAG RPNGGDKRTD DAGWGAVRPR VALTDPGDPG
     PAGVSPLPAD AVLPSAAPSG SASASASAPV SSVPSAAGSP TDVAVGAPPV QPKADSSSGS
     GSSLPIVAGV VAGLVLVAGV VFVVVRRRKS AVQPEVAVPP VPPQQPLPPS YQPPVPPEDN
     PYAR
//