ID A0A285QSD4_9ACTN Unreviewed; 404 AA.
AC A0A285QSD4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SOB84870.1};
GN ORFNames=SAMN06272789_5132 {ECO:0000313|EMBL:SOB84870.1};
OS Streptomyces sp. 1331.2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1938835 {ECO:0000313|EMBL:SOB84870.1, ECO:0000313|Proteomes:UP000219030};
RN [1] {ECO:0000313|Proteomes:UP000219030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1331.2 {ECO:0000313|Proteomes:UP000219030};
RA Varghese N., Submissions S.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; OBMJ01000001; SOB84870.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285QSD4; -.
DR Proteomes; UP000219030; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000219030};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SOB84870.1}.
FT DOMAIN 6..231
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..403
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 93
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 360
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 390
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 404 AA; 42222 MW; 3C1C914291FF7F1B CRC64;
MTTEAYVYDA IRTPRGRGKA TGSLYGTKPI DLVVGLIHEI RRRFPELDPA AIDDIVLGVV
SPIGDQGSDI ARIAAIAAGL PDTVAGVQEN RFCASGLEAV NLAAAKVRSG WEDLVLAGGV
ESMSRVKMAS DGGAWFADPM TAYETNFAPQ GIGADLIATI EGFSRTDVDA FAAESQARAA
KAQADGLFDR SVVPVRDRNG LVVLERDEFI RPGTTVETLA GLKPSFAAIG EAGGFDAVAL
QKYHWVEAID HVHHAGNSSG IVDGAALVAI GNREVGERYG LRPRARIVSA AVSGSEPTIM
LTGPAPATRK ALAKAGLTAA DIDLVEINEA FAAVALRFIR ELGFRADQVN VNGGAIALGH
PLGATGAMLL GTVIDELERR DLRYGLITLC VGGGMGIATI VERV
//
