ID A0A285QVK5_9ACTN Unreviewed; 3433 AA.
AC A0A285QVK5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SOB85564.1};
GN ORFNames=SAMN06272789_5853 {ECO:0000313|EMBL:SOB85564.1};
OS Streptomyces sp. 1331.2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1938835 {ECO:0000313|EMBL:SOB85564.1, ECO:0000313|Proteomes:UP000219030};
RN [1] {ECO:0000313|Proteomes:UP000219030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1331.2 {ECO:0000313|Proteomes:UP000219030};
RA Varghese N., Submissions S.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; OBMJ01000001; SOB85564.1; -; Genomic_DNA.
DR Proteomes; UP000219030; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17652; A_NRPS_CmdD_like; 2.
DR CDD; cd19540; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000219030}.
FT DOMAIN 962..1037
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2010..2085
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3085..3160
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3433 AA; 366097 MW; 51CB21FC9AB15726 CRC64;
MIPPSSAQRR LWFVSRLEGP SDTYNSSMAL RLRGPLDVPA LRAALTDVVG RHESLRTVFV
EHDGEPYQHI LDPAQATVEL AEAACTPQEL AAAADRAATH LFDLAVDLPL RPTLLTLGPD
DHVLVLVSHH IATDGWSMGP LLRDLTTAYE ARTAGREPGW EPLPVQYADY AAWQRELLGE
ESDPDSLVSR QLDYWRGVLA DLPEELALPA DRPRPAVATF AGGVVSTEVD AQVHRALNAL
ARDHGATLFM VLQSALAAML SRLGAGTDIP IGMSVAGRTD ESLDDLIGFF VNSLVLRTDV
SGDPSFTELL ARVRETDLGA LDHQDVPFER LVELVNPARL SARHPLFQVL LQLQNTDEVR
PEFPGVEADF EDLGWERAKF DLGAAFSELR DETGAEAGLI ASVEYSSDLF DRGTAQWLLD
CLVRLLGTVA ADPAARIADL PLLSDADRRA LAEWNATDRA VPAGDLHQLF EAQVARTPEA
EAVVFEDESL TYAELNARAN RLARHLVAAG AGPETLVALS LPRSVDLVVA TLAVTKSGAA
YLPIDQAYPA DRVAFMLADA RPALLLTDRP TETPEDVRTL VLADIAAEVA EQSADDLPAV
GDQARPAYVI YTSGSTGRPK GVVVTHRGIA NLAAAQVDRF GIVPGSRVLQ FASLSFDAAF
SELSTALLSG ATVVLAPSAR LMPGEPLAAL LAEQAVTHVT LPPAALAQQP AEGGLPDGMT
LVLAGEAAPA ELVERWLPGR RVINAYGPSE ATVCATMSLP LTDSAGVPPI GGPIWNSRAY
VLDGRLGLVP VGVIGELYVA GPGLARGYLK RPGLTAERFV ANPFEPGTRM YRTGDLVRRR
PDGQLEFVGR VDHQVKIRGF RIELGEVESV LSRCEGVRQA VVLAREDTPG DKRLVGYVVA
EQEGEPGLDP AALRELVGER LPEYMVPSAV VVLDTLPLTP NGKLDRNALP APDFAAGSTG
RAPRTPQEEI LCALFAEVLG LEAVGIDDGF FELGGHSLLA TRLISRVRTT LHAELSIREL
FQYPTVRTMA AALDQQGGVR TPLTPMPRTG DIPLSSAQQR LWFINRLDGP DGTYNSPVVL
RLRGPLNALA LEQALLDVVG RHETLRTVFP ETDGVPRQHV LENVAGRLHL TVHDCTATGP
AEALAAAVGR AFDIATDLPL GADLLRVDRE DHILALTFHH IATDGSSMGP LLRDLAAAYR
ARCTGRAPAW VPLPVQYADY TLWQRELLGE ESDPNSRLSQ QLDYWRGVLA DLPEELALPA
DRPRPADASL TGGVVSTGVD AEVHGALTAL ARDHGVTLFM VLQSALAAML SRLGAGTDIP
IGMSVAGRTD EALDELVGFF VNSLVLRTDV SGDPTFGELL ARVRETDLGA LDHQDVPFER
LVELVNPARL SARHPLFQVL LQLQNTADVR PEFPGVEADF EDFGWERAKF DLSAVFSERR
DETGGPAGLV ASLEYSADLF DRGTAQWLLD CLVRLLGTVA ADPAARIGAL ALLSDTDRKV
LAGWNATDHA VPAGDLHELF EAQVARTPEA VAVVFESESL TYAELNARAN RLARHLVAAG
AGPETLVALS LPRSVDLVVA TLAVTKSGAA YLPIDQAYPE DRQAFMLADA RPVLLLTDRA
MTVPAPRTTT RLVLEDIAEA VSADRADDLP AVGDQARPAY VIYTSGSTGR PKGVVVTHRG
IANLAAAQVD RFGIVPGSRV LQFASLSFDA AFSELSTALL SGATVVLAPS ARLMPGEPLA
ALLAEQAVTH VTLPPAALAQ QPAEGGLPDG MTLVLAGEAA PAELVERWLP GRRVINAYGP
SEATVCATMS LPLTGEDTTP PIGGPIWNTR AYVLDGRLGL VPVGVIGELY VAGPGLARGY
LNRPGLTAER FVADPFASGE RMYRTGDLVR RRPDGQLEFV GRVDHQVKIR GFRIELGEVE
AALTRCEGVR QAVVLAREDT PGDKRLVGYV VGEPGLDPAA LRDLVGERLP EYLVPSAVIV
LDAMPLTPNG KLDRNTLPAP DYTAGSTARA PRTAREEILC VLFAEVLGLE GVGIDDGFFE
LGGHSLLATR LISRIRATLD AELSIRELFQ YPTVRTMAAA LDEQGAVRTP LTPMPRTGDI
PLSSAQQRVW FINRIERTDE NAYYNCPFAL RLRGPLDAAA LEQALLDVVG RHESLRTVFP
ETDGVPRQQV LDDVAGRLRL TVHDCTATGP AEALAAAVGR GFDVTTELPL RAHLMVVGPE
EHVLLLVIHH IATDGSSMAP LMGDLAAAYR ARRAGRAPGW EPLPVQYADY TLWQRELLGQ
EDDPDSLAAA QIAYWKQALA GQPEEISLPV DRPRPAVSSH TGGMVHAELD AAVHKELAGL
ARAGGVTLFM LLHAAVATVL SRLGAGTDVS IGTPVAGRTD EALDGQVGFF VNTLVLRTDL
SGNPTFRELL ARVRDTDLGA FDHQDVPFER LVDVLNPARA AARNPLFQIV LALHNHAIEE
GEFAGLPAEA EPVELGAAKL DLNLNFTEVR DQAGTVTGLA AALEYSADLF DRSTAEWLLR
CLVDLLGVVT EDPDARIGAL PVLSAAGRRE LAAWNDTEWP VPATTLHGLV EAQAARTPGA
VAVRFADTEL DYAELDARAN RLAHHLLAHG AGPGQLVAVA VPRSPELPVA LLGVLKTGAA
YVPVDPGHPA DRIRQILAEA RPTVLLTDRA GARSEWATQV APAAPVDQAS PTSRADSAAR
VIVLDTESTR TELAARPATA PPPVPQAEAQ TAYVMYTSGS TGRPKGVVVD HPGLVNLLTE
LAQELPMAVG DVMLQQATAA FDISVAELFL PLMQGAATAL TTREEVRDPA VLAELIGRYG
VTVCQATPSL WQALLDERPD AVRGLRMMVG GDALPPALAA RLAVAGSRLV HCYGPTETTV
WSTTAELTAR PGTPPIGHPI RNTRAYVLDG YLNPVPPRVV GELYLAGTGL ARGYLGRPGL
TAERFVADPF AAGERMYRTG DLVRRRPDGQ LEFVGRVDHQ VKVRGFRIEL GEVEAVLAAH
PAVLQSAAAV REDGPGGQRL VGYVVPRPGA TPPAPEELRR HVGGRLPEYM VPSAVLVLDA
LPLTSNGKLD RTSLPAPAYA GTGRAPRTPR EEVLCALFAE VLDVATVGVD DSFFDLGGHS
LLATRLTSRI RAALGVEPGI RDLFAAPTPA GLAAALDDGG QGDALGVLFP LRPHGEATPL
FCVHPVAGVS WVYSGLLRHL DPQVPVFGLQ ARGLTEPGAL PRSIAEMAED YVAEIRKARP
HGPYRLLGWS FGGQVAHAVA VRLQAEGEQV EQLTVLDGFP VHPEAGRLPA DAPEPQTLTA
LLHSLGHSVP DPAEGGGELD RARLREVLEQ AGSPLSGLDE DRLAALVAVF ANNAELVHTG
VSGVYDGDLI HVTATLGKPA DAPTAEDWRP YVTGAVHRHD LACHHGALTQ PEPIAAVSAV
LAGQAPTPRR TTA
//
