ID A0A285QXC6_9ACTN Unreviewed; 778 AA.
AC A0A285QXC6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SOB84712.1};
GN ORFNames=SAMN06272789_4971 {ECO:0000313|EMBL:SOB84712.1};
OS Streptomyces sp. 1331.2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1938835 {ECO:0000313|EMBL:SOB84712.1, ECO:0000313|Proteomes:UP000219030};
RN [1] {ECO:0000313|Proteomes:UP000219030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1331.2 {ECO:0000313|Proteomes:UP000219030};
RA Varghese N., Submissions S.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; OBMJ01000001; SOB84712.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285QXC6; -.
DR Proteomes; UP000219030; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000219030};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 246..378
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 89..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 78973 MW; D96E8EEE3E7B85AA CRC64;
MRKPSSAVPA AVVGGRLAAL GRFCFRHRRW VLGFWAAVLV VGVLIGGRVF AGSVAGASSA
SAEADRGSAV VAAADPSAGT VTAVVDEKAV DGQQADGKPA DGKPVGGKPG DGKPAAGKPG
DGKPVDDPAV RAAVQKATAE IAGLPGVSSA LDGYGSGPAS AALRSADGTA SLVTVRMADT
ATSGQTDAVT QRLAALNGAG GAHVTVGGDL VLQQEVKKQT EQDTRFGEMV TLPLTLVVMV
LVFGGLAAAS LPVIGAVASV GGALLAMFGF SRIMDIDTSV LPIATVLGLG LSIDYALLMV
NRFREERGHG ADIAAAVERT AATAGRTVAF SGLTVAVALS GLFVFTSPVL GAVAAAGVSV
VVIAVAAALT LIPALLGFAG SRIKAPTAPV PDEGFFSRTV RRVRKRAVLV ALACVAVLMA
AGAPFLHADM RNSGAAVLPT SSAGRQVADT IDQRFPDVAA APITVVVEGG ASVAQAYADD
VVAKLPGVSG VRAVSPVSAG VSTIDVLVHG DPQGGQAKHV VEELRADRGG LKTYVTGGAA
SVVDFRQELL SRGPWALGLV AAGTLVLLFL MTGSVVMPVK ALLMNLLSLG ASLGALTLVF
QDGWFSGLLG FSPTGGLETF IPVLVFAFAF GLSMDYEVFL LARIKELHSR GYSCTRAVEL
GVQRSGRIIT SAALLMVIVF AGFALGDMLM VKQMGIALAV AVAVDATLVR CLLVPAAMSL
FGEFNWWAPA PLKRLHRRFG LSEHVELPEI GQAAASLPSS AAIPAQRPAV KDLVGSET
//
