ID A0A285SCV9_9RHOB Unreviewed; 477 AA.
AC A0A285SCV9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=SAMN05877831_10475 {ECO:0000313|EMBL:SOC04961.1};
OS Rhodobacter maris.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Rhodobacter.
OX NCBI_TaxID=446682 {ECO:0000313|EMBL:SOC04961.1, ECO:0000313|Proteomes:UP000219111};
RN [1] {ECO:0000313|Proteomes:UP000219111}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA276 {ECO:0000313|Proteomes:UP000219111};
RA Varghese N., Submissions S.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; OBMT01000004; SOC04961.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285SCV9; -.
DR Proteomes; UP000219111; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:SOC04961.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:SOC04961.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SOC04961.1}.
FT DOMAIN 4..284
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 317..467
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 477 AA; 50692 MW; DB60EAE3EBE81B77 CRC64;
MIYPTILCGG SGTRLWPLSR KSYPKQFVPL LGEETLFQAS ARRLTGAGYA APVVLTNSDF
RFIVTEQLAA VGIDPGAILI EPEGRNTAPA VLAAALHLHA IDAEAVLLVA PSDHAIPDAA
AFQAAVQRGL AAVDQGQIVT FGITPTRPET GYGYLELAHA PEASEAPVAL TRFVEKPDLA
RAEEMVAAGS FLWNAGIFLF RAADMIAAFE AHAPEVLAPV RAALAGAQTD LGFLRLAPEP
WGLAPEISLD YAVMERAANL SAVPFSGAWS DLGGWDAVRA AGPEDATGTV TSGAATAIDC
TASLLRSESE GLELVGIGLD NIIAVATNDA VLVADMSRAQ DVKKAVEALK ARKAPQAVQF
PKDHRPWGWF ETLALADRFQ VKRIVVHPGA ALSLQSHHHR SEHWIVVQGT AKVTVDETVQ
LVTENQSVYV PLGAIHRMEN PGKVPMVLIE VQTGSYLGED DIIRYDDVYA RGQGAKG
//
