ID A0A285VKZ2_9MICO Unreviewed; 409 AA.
AC A0A285VKZ2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=threonine ammonia-lyase {ECO:0000256|ARBA:ARBA00012096};
DE EC=4.3.1.19 {ECO:0000256|ARBA:ARBA00012096};
GN ORFNames=SAMN05421879_102234 {ECO:0000313|EMBL:SOC53876.1};
OS Ornithinimicrobium cerasi.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Ornithinimicrobiaceae; Ornithinimicrobium.
OX NCBI_TaxID=2248773 {ECO:0000313|EMBL:SOC53876.1, ECO:0000313|Proteomes:UP000219688};
RN [1] {ECO:0000313|Proteomes:UP000219688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA17B2 {ECO:0000313|Proteomes:UP000219688};
RA Varghese N., Submissions S.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; OBQK01000002; SOC53876.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285VKZ2; -.
DR STRING; 1122622.GCA_000421185_02778; -.
DR Proteomes; UP000219688; Unassembled WGS sequence.
DR GO; GO:0004794; F:L-threonine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006567; P:threonine catabolic process; IEA:InterPro.
DR CDD; cd04886; ACT_ThrD-II-like; 1.
DR CDD; cd01562; Thr-dehyd; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR044561; ACT_ThrD-II-like.
DR InterPro; IPR005789; Thr_deHydtase_catblc.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01127; ilvA_1Cterm; 1.
DR PANTHER; PTHR48078:SF6; ACT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48078; THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS51671; ACT; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Isoleucine biosynthesis {ECO:0000256|ARBA:ARBA00022624};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000219688}.
FT DOMAIN 335..409
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 409 AA; 43120 MW; 9F3882EEC9D305C6 CRC64;
MPTSPAVTLD DVLAAREVLA EVLTPTPVER SRSLSERTGL EVHLKCENLQ RAGSFKMRGA
YTRMARLTEE ERGRGVVAAS AGNHAQGVGL AARLLGIAAT VYMPFGAAMP KLAATRGYGA
TVVQVGTTID DCIEEARRHE QETGAVFIPP FDHPDIVAGQ GTCGLEILEQ VPDVRTILVC
TGGGGLLAGI ATAVKALRPE VTVVGVQAEE AAAWPPSLTA GHPVALGRMS TMADGIAVGR
PGDVPFGLVA ELVDGVETVS EDSIARAVLF LAERAKLVVE PAGAAATAHL MDLGEDAARR
YEGPVVAVVS GGNIDPLLLL RIIRTGLTVA GRYLQLRVRV PDRPGELAAV LALLAELRCN
VLEVQHHRRV VGLKVHEVAI SMTLETTGHD HSAEVVRALQ DRSYTVEQV
//
