ID A0A285VNF3_9MICO Unreviewed; 339 AA.
AC A0A285VNF3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=SAMN05421879_10583 {ECO:0000313|EMBL:SOC55437.1};
OS Ornithinimicrobium cerasi.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Ornithinimicrobiaceae; Ornithinimicrobium.
OX NCBI_TaxID=2248773 {ECO:0000313|EMBL:SOC55437.1, ECO:0000313|Proteomes:UP000219688};
RN [1] {ECO:0000313|Proteomes:UP000219688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA17B2 {ECO:0000313|Proteomes:UP000219688};
RA Varghese N., Submissions S.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
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DR EMBL; OBQK01000005; SOC55437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285VNF3; -.
DR STRING; 1122622.GCA_000421185_00615; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000219688; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR Pfam; PF00293; NUDIX; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000219688}.
FT DOMAIN 6..144
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT DOMAIN 167..339
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 339 AA; 36026 MW; 5AF329F02B8FC7FE CRC64;
MTSRFQVVPA AYVALLRDGP DGVEVLLQLR SGTGYMDGRW AHGAAGHVEL GESALAAAAR
EAAEELGVGV DPADLGHVAT VHRTVAVHRP SEERVDLFVS TRRWSGEPSP LEPGKVAELR
WWPLTALPDD VVPHERAALD VLVRREVPGA AAGDAGPTLL TLGFDQRLTL VAAVGTNGVI
GDGARMPWHL PEDLRFFRRT TTGGTLLMGR GTWDSIGRAL PGRRTIVITR QRSWAAPGAE
VAHSLEEALA LAGDGEVFVV GGGEVYAQTI DHASRLLVTE VGLAPPGGTR FPEIDPRVWR
EVARVPGSGD VLGWVTWERS AAGMGGWPTR SDADHSTGA
//
