ID A0A285VUN5_9MICO Unreviewed; 983 AA.
AC A0A285VUN5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Multisubunit sodium/proton antiporter, MrpA subunit /multisubunit sodium/proton antiporter, MrpB subunit {ECO:0000313|EMBL:SOC57742.1};
GN ORFNames=SAMN05421879_11546 {ECO:0000313|EMBL:SOC57742.1};
OS Ornithinimicrobium cerasi.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Ornithinimicrobiaceae; Ornithinimicrobium.
OX NCBI_TaxID=2248773 {ECO:0000313|EMBL:SOC57742.1, ECO:0000313|Proteomes:UP000219688};
RN [1] {ECO:0000313|Proteomes:UP000219688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA17B2 {ECO:0000313|Proteomes:UP000219688};
RA Varghese N., Submissions S.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; OBQK01000015; SOC57742.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285VUN5; -.
DR STRING; 1122622.GCA_000421185_00312; -.
DR Proteomes; UP000219688; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1200; NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ; 1.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000219688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..107
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 130..400
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 615..677
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 691..767
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 821..943
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 983 AA; 103495 MW; 121B4597784983E3 CRC64;
MITALLVLHV LAAAIAPSLV RRLGSSRAFT LLALVPAAAT AWAALRLGPL RTTGTAHAET
LNWVPDLHIT LAFRVDALAW LMTLVVSGIG ALVLLYCAHY VDDEDEGRVG LMAGSLVAFA
GAMLGLVTTD DLLVLYVFWE ITTVLSYLLI GYQTTSAAST RAAKQALIIT TAGGLAMLVG
IVLLGHTGGT YSISELVADP PTGTVVTTAV VLLLVGAITK SALVPFHFWL PGAMVAPTPI
SAYLHAAAMV KAGVYLVARL APGYADLPAW QVTLLVLGGG TMLVGAFRAT RQTDLKLLLA
YGTVSQLGFL TLLLAYGSPG ATLAGLTLVL AHALFKSCLF LTVGTIDHAM GTRDIRRLVG
VRQKMPLLAL SATVAAMSMA GLPVLLGFVG KEAALAAVLH PVDGWRSLQG AAGVVVVIGS
VLTMAYSARF VWGAFTDGAR PPVGKPMPPR WHAPSWLLVA VPGLLSVLGL VLGPASPLLE
SVLEPHTATV DHLADVYPVH LGLWHGLGLP LLVSALVWLL GAAWWGLQAR RPVEVPVPIW
PFDAGRSYQH TVRGLDRVAL ETTGFVQRGS LPMLLGTIFT VLVVLPGSWL LLEDPAWPQE
VRLSDGPGQV ATGAIVVIAA FLATRARRRL RAVFLVGVTG YGTAYLYLLH GAPDLALTQV
LVETVTLVVL VLVLRRLSGR FPDDPTVLTR RIRALLGVAV GAVIGAGALL ATGSRVHAPA
GVGLAERAVD YGGGYNIVNV ILVDVRAWDT MGELSVVLAC ATGVASLTFL TDENLERVRA
GLRQVRGQRL AAVSRAEEPA TSTVPWVAGA GLLDQSRRST ILEIVTHLVF HTIILWSVYL
LFAGHNQPGG GFSAGIVAGL ALCLRYLAGY GAELRAALPV MPTVLLGTGL FIAGGSAVLP
MLFGSPALRT WIADVQVPLL GEVHVVTSLL FDVGVYLVVL GLMLDILRSF GTGIDAQIRT
ERQEREEREA QLVGSAEPEG VTR
//
