ID A0A285X406_9FLAO Unreviewed; 392 AA.
AC A0A285X406;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=SAMN06296241_1636 {ECO:0000313|EMBL:SOC80091.1};
OS Salinimicrobium sediminis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salinimicrobium.
OX NCBI_TaxID=1343891 {ECO:0000313|EMBL:SOC80091.1, ECO:0000313|Proteomes:UP000219193};
RN [1] {ECO:0000313|Proteomes:UP000219193}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12641 {ECO:0000313|Proteomes:UP000219193};
RA Varghese N., Submissions S.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; OCMF01000002; SOC80091.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A285X406; -.
DR OrthoDB; 9764892at2; -.
DR Proteomes; UP000219193; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF171; ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000219193};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SOC80091.1}.
FT DOMAIN 5..262
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 270..391
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 378
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 392 AA; 41210 MW; AFD5B509395666A1 CRC64;
MNKEVVIVSA ARTPIGSFLG SLSTVPATKL GSIAIKGALA KINLKPEMVE EVLMGNVVQA
GNGQAPARQA ALGAGIPTSV PCTTVNKVCA SGMKAVMQAA QAISLGDASI VVAGGMENMS
LIPHYLHLRN GHKFGPAQME DGMQKDGLVD AYDHNAMGVA ADHCAKEHNY TREEQDKFAI
QSYERSRKAW EDGKFNEEVV PVEVPQRKGD PVIVKEDEEY KNVKMDKIAS LRPAFGKEGT
VTAANASTIN DGAAALVLMS REKAEELGLE ILASIKGFAD AATDPIWFTT APAKALPKAL
DKAGISIDKV DYFEFNEAFS VVGLVNMKIL GLEDKNVNVN GGAVSLGHPL GCSGARILVT
LLNVLKQNDG KIGAAAVCNG GGGASAMILE RQ
//
