ID   A0A285X5V7_9FLAO        Unreviewed;       302 AA.
AC   A0A285X5V7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Lactate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SAMN06296241_2191 {ECO:0000313|EMBL:SOC80638.1};
OS   Salinimicrobium sediminis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Salinimicrobium.
OX   NCBI_TaxID=1343891 {ECO:0000313|EMBL:SOC80638.1, ECO:0000313|Proteomes:UP000219193};
RN   [1] {ECO:0000313|Proteomes:UP000219193}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.12641 {ECO:0000313|Proteomes:UP000219193};
RA   Varghese N., Submissions S.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; OCMF01000002; SOC80638.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A285X5V7; -.
DR   OrthoDB; 9805416at2; -.
DR   Proteomes; UP000219193; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219193}.
FT   DOMAIN          27..295
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          132..245
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   302 AA;  33988 MW;  ADA6F8917ABD1282 CRC64;
     MKFQKIVCVD HTKLEPWALE ELQGYSEEKI EVFEDYPGSR KEIIARIKNA DAVIVSWRTK
     LDKEILSKCS NLKYIGMACS LYDNESANVA VDFARSRGIL VKGIKDYGDP GVAEFIISEL
     IRLFHGLGDY QWKEMPVELT DKKIGIIGLG TTGQLLAQCL LPFGADLYYF SRSRKKEWEK
     KGVTYLELEE LLSSVDVVSL HLPKNTKILG AKEFDIFGTG KILINTSLGL PFQEAEFVDW
     IKKGGNFAIF DGDGKKELSE GTEELRGMIT ATKSAGWAAE TQKRLSEKVL QNLKDSSEEI
     FH
//