ID A0A286DNG3_9ACTN Unreviewed; 493 AA.
AC A0A286DNG3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338};
DE EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338};
GN ORFNames=SAMN06297387_1025 {ECO:0000313|EMBL:SOD60074.1};
OS Streptomyces zhaozhouensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1300267 {ECO:0000313|EMBL:SOD60074.1, ECO:0000313|Proteomes:UP000219072};
RN [1] {ECO:0000313|EMBL:SOD60074.1, ECO:0000313|Proteomes:UP000219072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7095 {ECO:0000313|EMBL:SOD60074.1,
RC ECO:0000313|Proteomes:UP000219072};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000985};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3.
CC {ECO:0000256|ARBA:ARBA00004941}.
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DR EMBL; OCNE01000002; SOD60074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A286DNG3; -.
DR OrthoDB; 4899737at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000219072; Unassembled WGS sequence.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Lyase {ECO:0000313|EMBL:SOD60074.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000219072}.
FT DOMAIN 108..312
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 376..413
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 493 AA; 52372 MW; 17D33A9F3ECA7CBC CRC64;
MTGGGAREPD QADTGRLAAT LGARTRSMVF GTAEPSAIDG ELELLTTIDL AHVVMLAERR
LVPGRDAAEL LRHVGRLRAD GFRELHHRPM PRGLYLMYEA HLVSALGPET GGKLHTGRSR
NDIKATATAM RLRAELAELL GQTLRLQAVL LCRARAYREV VMPVYTHYQP AMPVTYGYYL
AGVATALERD IAALRHTLGE LDRCPLGAGA VSGTDLPIDP ARTAALLGFE APVAHAMDAV
ASRDTALRAV AGAAGVGLTL SRLATDLQLW STQEFGFVTF PERLVGGSSA MPQKRNAFLL
EHVKGRAGAA VGVWTGAASS MKSTPFTNSI EVGTEAVSEV WGALAGTVES VLLAQVLVSG
GRPVAARMAA RAEEGFVTAT VVANRLVRQG VPFRTAHHTV GAAVRRAVES GSTRLTGADL
PAGSVPPLDE VTAEHRYGGG PGMFDTSFDE VRRRLVDHAG WLRGRRESWA VARQRLDGAV
AELTARPEGN EAP
//
