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Database: UniProt
Entry: A0A286DW94_9ACTN
LinkDB: A0A286DW94_9ACTN
Original site: A0A286DW94_9ACTN 
ID   A0A286DW94_9ACTN        Unreviewed;       603 AA.
AC   A0A286DW94;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Pyruvate dehydrogenase (Quinone) {ECO:0000313|EMBL:SOD62932.1};
GN   ORFNames=SAMN06297387_10895 {ECO:0000313|EMBL:SOD62932.1};
OS   Streptomyces zhaozhouensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1300267 {ECO:0000313|EMBL:SOD62932.1, ECO:0000313|Proteomes:UP000219072};
RN   [1] {ECO:0000313|EMBL:SOD62932.1, ECO:0000313|Proteomes:UP000219072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7095 {ECO:0000313|EMBL:SOD62932.1,
RC   ECO:0000313|Proteomes:UP000219072};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; OCNE01000008; SOD62932.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A286DW94; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000219072; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:SOD62932.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219072};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          4..119
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          198..328
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          389..544
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   REGION          554..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  65134 MW;  04C7E6F48A701C79 CRC64;
     MTEKVADHVL DRLREWGVSH VFGYPGDGIN GLLAAWERAG DRPRFLQARH EEMAAFQAVG
     YAKFSGGVGV CAATSGPGAV HLLNGLYDAK LDHVPVVALV GQTARSAMGG SYQQEIDLHT
     LFKDVASAYL EVVNVPEQLP NVLDRALRTA RALRAPTAVI IPADVQDLDY TPPGHAFKMV
     PSSIGASGWT ATPDEAALDR AAEVLNAGEK VAMLVGQGAA GAADEVVETA RVLQAGIAKA
     LLGKDVLPDT LPGVTGGIGL LGTRPSYELM RDCDTLLTVG SSLPYSQFLP EYDQARAVQI
     DLDPHQIGMR YPYEVNLVGD ARDTLRRLLP RLRPSENGER WRTSMEKAVE RWYDVLARRA
     EVEADPVNPE YVAHCLDRLV PENAVLTADS GSVANWYARH VRMRGRMRGS LSGTLASMGC
     AVPYAIAAKF AMPDRPAIAL VGDGAMQMNG LAELVTAARY RHEWSDPRLV VAVWNNRDLN
     QVSWELRAMG GAPRFEASQS LPDVRYADFA RSLGLEGIRV EKPADVEDGW RRALAADGPA
     VVEFLTDPSV PPIPPHASWE QASATAKSLA RGDGDRGAVL RQGVKAKLQD YLPGRRHRDG
     GDG
//
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