ID   A0A286E6R4_9ACTN        Unreviewed;      1113 AA.
AC   A0A286E6R4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Subtilase family protein {ECO:0000313|EMBL:SOD66579.1};
GN   ORFNames=SAMN06297387_12646 {ECO:0000313|EMBL:SOD66579.1};
OS   Streptomyces zhaozhouensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1300267 {ECO:0000313|EMBL:SOD66579.1, ECO:0000313|Proteomes:UP000219072};
RN   [1] {ECO:0000313|EMBL:SOD66579.1, ECO:0000313|Proteomes:UP000219072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7095 {ECO:0000313|EMBL:SOD66579.1,
RC   ECO:0000313|Proteomes:UP000219072};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; OCNE01000026; SOD66579.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A286E6R4; -.
DR   OrthoDB; 9798386at2; -.
DR   Proteomes; UP000219072; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR017297; Peptidase_S8A_DPH-A.
DR   PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR   PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PIRSF; PIRSF037854; Dihydropyridine_esterase; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000219072};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          238..502
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          269..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        247
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        280
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        455
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   1113 AA;  114294 MW;  407392A4CB8B9246 CRC64;
     MRFRQGREGG RAAGRRTGFR VTTAATATAV ALAVTAGLTT TAQAETSRAG EVPTVTEKQA
     GGERLTLITG DQVVLGHDGE VAGLIPAEGR ESIPVRTARV GDSVQVLPAD VLPLIHEGKL
     DRRLFDITAL GAARDQSDAL RLIVSYSGDR SANELFADAA PEVGATLASV NGEALSVADA
     TDAAALWGAL TERADGAATL STVPAVESVA LDGVVTKSLD VSVPQIGAPD AWEAGFDGTG
     VTVAVLDTGI AADHPDLGAD RVIAEQNFSD SDSASDRDGH GTHVASTVAG TGDPYNGVAP
     GASLLNGKVL DDGGSGWESD IIEGMEWAVG EGADIVSMSL GGPALDEVDP MEEAVDNLSA
     ESDSLFVIAA GNSGPFEASI GSPGTAESAL TVGAVDDDDA LADFSSIGPR LRDGGVKPDV
     TAPGVDIAAA GAEGAAIWEY GTPVDDTHVA ISGTSMATPH VAGAAALLAQ ADPDLTGEQL
     KAVLAGSAIG ADGYTPFQQG TGRVDVPAAL AQQVITEGAG LNFGRVEFPH EDAEPVTREL
     TYRNLGDADV TLELTAEGTD PEGAPAPEGL FSLSAEEVTV PAGSTATVEV TAATSAGEAF
     GAHTLTVTAT GDDTTVTAVG AVEREEELFD LTVEGTDREG NPSAEFDATV IDTATFDSYR
     LLGSEGTATA RVPEGEYLVE VGHYLIDEEA EELVGLDWLV EPEVQVSEAT TVDADASVAA
     PVEWTVEDEA AGENDLNVGF NLLDPESGET TLSYGWSAGG LAQGFHTGAL DTPDNPDAFL
     GTADANWLNT EENARYADAT TLPGEFPTGL TEHLALDETA LLRTSVGSSV PDTTGSLFVY
     PEASGWVSSP IVALPLTVDL HVRAGTGWAM DFTQDTEEVP FAVFGYTDGY TAYEAGETHD
     VTFNVGVHGP SADGGTGLFR EGELLYGTAG PFTDGGGNGA WSEYDAGSTT LYRDGEEFAT
     AESPFEETEF TLPAEEAEYR LETTVSRSAP VAAVSTEVSA AYTFTSAATE EPTELPFSAV
     RFAPELALDS TTPAGETLDV PVTVEGAAAD NADALVLTYS TDRGESWQDV EVVDGVARIP
     SPEAGGSVSL HAEIEDGRGN ALEQTILDAY LTR
//