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Database: UniProt
Entry: A0A286E8F7_9NEIS
LinkDB: A0A286E8F7_9NEIS
Original site: A0A286E8F7_9NEIS 
ID   A0A286E8F7_9NEIS        Unreviewed;       556 AA.
AC   A0A286E8F7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000256|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000256|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000256|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000256|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000256|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000256|HAMAP-Rule:MF_01543};
GN   ORFNames=SAMN02746062_00834 {ECO:0000313|EMBL:SOD67197.1};
OS   Alysiella filiformis DSM 16848.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Alysiella.
OX   NCBI_TaxID=1120981 {ECO:0000313|EMBL:SOD67197.1, ECO:0000313|Proteomes:UP000219669};
RN   [1] {ECO:0000313|EMBL:SOD67197.1, ECO:0000313|Proteomes:UP000219669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16848 {ECO:0000313|EMBL:SOD67197.1,
RC   ECO:0000313|Proteomes:UP000219669};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC         EC=6.3.4.3; Evidence={ECO:0000256|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01543}.
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DR   EMBL; OCNF01000005; SOD67197.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A286E8F7; -.
DR   OrthoDB; 9761733at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000219669; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_01543, ECO:0000313|EMBL:SOD67197.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW   Rule:MF_01543}; Reference proteome {ECO:0000313|Proteomes:UP000219669}.
FT   BINDING         64..71
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   556 AA;  58963 MW;  652F4DFB783AB309 CRC64;
     MQTDVQIAQA AKLQHINHIA AQIGLQAEQL EHYGKYKAKI NPQDAFRLPA KRGKLILVTA
     INPTPAGEGK TTVTIGLTDA LNHIGKNAMV AMREPSLGPV FGVKGGAAGG GYAQVVPMED
     INLHFTGDFH AISAANNLLA AMLDNHIYQG NALQIDPKRV LWRRVVDMND RQLRNIINGL
     GKPTDGVMRP DGFDITVASE VMAIFCLAKD LVDLKQRLGN ILVAYSVSGS PIYARDLNAH
     GAMTALLKDA LKPNLVQTLA GSPALVHGGP FANIAHGCNS VLATQVARHL SDYTVTEAGF
     GADLGAEKFC DIKCRLADIQ PDCAVVVATV RALKYNGGVA KADLNAENVD AVQRGLPNLL
     KHINNLQNVF GLPVVVALNQ FVSDSENELA AIQAACTQIG AQCALTQVWE KGGTGGVDLA
     EKVVQAIETH TPKFKFAYDV NLPIADKITA IATQIYGAAK VEFAAEAQAE MANLARLGLD
     KLPICMAKTQ YSLSDDANLL GCPSDFTLHV RGMTVSAGAG FIVALCGNMM KMPGLPKVPA
     AEKIDVDENG VISGLF
//
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